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1. (WO2008102994) COMPOSITION COMPRISING DECURSIN DERIVATIVE FOR TREATING AND PREVENTING ATOPIC DERMATITIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/102994    International Application No.:    PCT/KR2008/001017
Publication Date: 28.08.2008 International Filing Date: 21.02.2008
IPC:
C07D 493/04 (2006.01)
Applicants: PARK, Yong Jin [KR/KR]; (KR) (For US Only).
KIM, Joo Hwan [KR/KR]; (KR).
SONG, Gyu Yong [KR/KR]; (KR) (For US Only).
WOO, Jin Suk [KR/KR]; (KR) (For US Only).
KIM, Jin Sook [KR/KR]; (KR) (For US Only).
KIM, Dong Hee [KR/KR]; (KR) (For US Only).
LEE, Jee Hyun [KR/KR]; (KR) (For US Only).
YUN, Chi-Young [KR/KR]; (KR) (For US Only).
KIM, In Sik [KR/KR]; (KR) (For US Only).
LEE, Ji Sook [KR/KR]; (KR) (For US Only).
KIM, Young Kook [KR/KR]; (KR) (For US Only).
RHO, Mun Chual [KR/KR]; (KR) (For US Only).
CHOI, Yong Seok [KR/KR]; (KR) (For US Only)
Inventors: PARK, Yong Jin; (KR).
KIM, Joo Hwan; (KR).
SONG, Gyu Yong; (KR).
WOO, Jin Suk; (KR).
KIM, Jin Sook; (KR).
KIM, Dong Hee; (KR).
LEE, Jee Hyun; (KR).
YUN, Chi-Young; (KR).
KIM, In Sik; (KR).
LEE, Ji Sook; (KR).
KIM, Young Kook; (KR).
RHO, Mun Chual; (KR).
CHOI, Yong Seok; (KR)
Agent: SHIN, Dong In; 5F, Dong Seo Bldg., 1451-30, Seocho-dong, Seocho-gu, Seoul 137-867 (KR)
Priority Data:
10-2007-0018057 22.02.2007 KR
Title (EN) COMPOSITION COMPRISING DECURSIN DERIVATIVE FOR TREATING AND PREVENTING ATOPIC DERMATITIS
(FR) COMPOSITION RENFERMANT UN DÉRIVÉ DE LA DÉCURSINE POUR TRAITER ET PRÉVENIR LA DERMATITE ATOPIQUE
Abstract: front page image
(EN)The present invention relates to the novel decursin derivatives, the preparation thereof and the composition comprising the same. The novel decursin derivatives of the present invention showedpotent inhibiting activity of the release of MCP-1, IL-6 and IL-8 induced by dermite in THP-1 or EoL-1 cell, therefore the compounds can be useful in treating or preventing atopic dermatitis.
(FR)L'invention concerne de nouveaux dérivés de la décursine, un procédé de préparation de ceux-ci et une composition comprenant un tel composé. Ces nouveaux dérivés de la décursine présentent une puissante activité d'inhibition de la libération de MCP-1, de l'IL-6 et de l'IL-8 induite par une dermite dans une cellule THP-1 ou EoL-1, ces composés pouvant donc être utiles pour traiter ou prévenir la dermatite.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)