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1. (WO2008102568) BONE/CARTILAGE FORMATION-STIMULATING AGENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/102568    International Application No.:    PCT/JP2008/000316
Publication Date: 28.08.2008 International Filing Date: 22.02.2008
IPC:
C08B 37/00 (2006.01), A61K 31/726 (2006.01), A61P 19/10 (2006.01)
Applicants: PG RESEARCH CO., LTD. [JP/JP]; Century Plaza 101, 4-13-11, Hanakoganei, Kodaira-shi, Tokyo 1870002 (JP) (For All Designated States Except US).
TOHOKU UNIVERSITY [JP/JP]; 1-1 Katahira, 2-chome, Aoba-ku, Sendai-shi, Miyagi 9800812 (JP) (For All Designated States Except US).
MIYAZAKI, Tatsuya [JP/JP]; (JP) (For US Only).
MIYAUCHI, Satoshi [JP/JP]; (JP) (For US Only).
MATSUZAKA, Satoshi [JP/JP]; (JP) (For US Only).
SUZUKI, Osamu [JP/JP]; (JP) (For US Only)
Inventors: MIYAZAKI, Tatsuya; (JP).
MIYAUCHI, Satoshi; (JP).
MATSUZAKA, Satoshi; (JP).
SUZUKI, Osamu; (JP)
Agent: OKUDA, Noritsugu; 1-2354-430, Yurigaoka Moriya-shi, Ibaraki 3020110 (JP)
Priority Data:
2007-042272 22.02.2007 JP
Title (EN) BONE/CARTILAGE FORMATION-STIMULATING AGENT
(FR) AGENT DE STIMULATION DE LA FORMATION D'OS/CARTILAGE
(JA) 骨軟骨形成促進剤
Abstract: front page image
(EN)Disclosed is a mixture of: a bone/cartilage formation-stimulating agent comprising sulfated galactosaminoglycan having 0.6 or more sulfate ester group(s) on average per one constituent monosaccharide or a salt thereof as an active ingredient; and a factor having a bone/cartilage formation-stimulating activity or a bone defect filler (BMP, TGF-&bgr;, FGF, IGF, insulin, PDGF, HGF, midkine, pleiotrophin, collagen, gelatin, proteoglycan, fibronectin, osteocalcin, osteopontin, osteonectin, bone sialoprotein, hydroxyapatite, dicalcium phosphate anhydride, dicalcium phosphate dihydrate, &agr;-tricalcium phosphate, amorphous calcium phosphate, octacalcium phosphate, &bgr;-tricalcium phosphate, PLLA, PLGA, titanium, decalcified bone, autogenous bone, etc.).
(FR)L'invention porte sur un mélange de : un agent de stimulation de la formation d'os/cartilage comprenant un galactosaminoglycane sulfaté ayant en moyenne 0,6 groupe ester sulfate ou plus par monosaccharide constitutif ou un sel de celui-ci comme ingrédient actif ; et un facteur ayant une activité de stimulation de la formation d'os/cartilage ou un remplissage de défaut osseux (BMP, TGF-β, FGF, IGF, insuline, PDGF, HGF, midkine, pléiotrophine, collagène, gélatine, protéoglycane, fibronectine, ostéocalcine, ostéopontine, ostéonectine, sialoprotéine d'os, hydroxyapatite, anhydride de phosphate dicalcique, dihydrate de phosphate dicalcique, phosphate α-tricalcique, phosphate de calcium amorphe, phosphate octacalcique, phosphate β-tricalcique, PLLA, PLGA, titanium, os décalcifié, os autogène, etc.).
(JA) 構成単糖当たり平均0.6個以上のエステル硫酸基を含有する硫酸化ガラクトサミノグリカン又はそれらの塩を有効成分として含有する骨軟骨形成促進剤及び、骨軟骨形成促進作用を有する因子あるいは骨補填剤(BMP、TGF-β、FGF、IGF、インスリン、PDGF、HGF、ミッドカイン、プレイオトロフィン、コラーゲン、ゼラチン、プロテオグリカン、フィブロネクチン、オステオカルシン、オステオポンチン、オステオネクチン、骨シアロタンパク、ハイドロキシアパタイト、無水リン酸ジカルシウム、リン酸ジカルシウム2水和物、リン酸α-トリカルシウム、非晶質リン酸カルシウム、リン酸オクタカルシウム、リン酸β-トリカルシウム、PLLA、PLGA、チタン、脱灰骨、自家骨等)との混合物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)