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Pub. No.:    WO/2008/102374    International Application No.:    PCT/IN2008/000098
Publication Date: 28.08.2008 International Filing Date: 19.02.2008
C07D 305/14 (2006.01), A61K 31/337 (2006.01), A61P 35/00 (2006.01)
Applicants: DABUR PHARMA LIMITED [IN/IN]; 3, Factory Road, Adjacent to Safdarjung Hospital, New Delhi 110 029 (IN) (For All Designated States Except US).
MISHRA, Bhuwan, Bhaskar [IN/IN]; (IN) (For US Only).
VARDHAN, Anand [IN/IN]; (IN) (For US Only).
AGARWAL, Shiv, Kumar [IN/IN]; (IN) (For US Only)
Inventors: MISHRA, Bhuwan, Bhaskar; (IN).
VARDHAN, Anand; (IN).
AGARWAL, Shiv, Kumar; (IN)
Agent: MAJUMDAR, Subhatosh; S. Majumdar & Co., 5, Harish Mukherjee Road, Calcutta 700 025 (IN)
Priority Data:
253/KOL/2007 20.02.2007 IN
Abstract: front page image
(EN)A process for preparation of Amorphous Form of Docetaxel comprising: i. preparation of a solution or suspension of Docetaxel in an organic solvent or mixtures thereof; ii. evaporation of the solvent or mixtures thereof from the solution or suspension of step i ) under reduced pressure to obtain a solid substance; iii. optionally further dissolving or suspending the solid substance of step ii) in an organic solvent or mixtures thereof and evaporation of the solvent or mixtures thereof from the solution or suspension under reduced pressure to obtain a solid substance; iv. further optionally repeating step iii) one or more times; v. drying the solid substance obtained from step ii), iii) or iv) to give the amorphous form of Docetaxel. An amorphous form of docetaxel obtained by the process. A composition comprising amorphous form of Docetaxel along with pharmaceutically acceptable excipients adapted for therapy for cancer of various origins.
(FR)L'invention porte sur un procédé de préparation d'une forme amorphe du Docétaxel comprenant les étapes suivantes: i) préparation d'une solution ou d'une suspension de Docétaxel dans un solvant organique ou ses mélanges; ii). évaporation du solvant ou des mélanges de la solution ou de la suspension de l'étape i); iii). facultativement nouvelle dissolution ou suspension de la substance solide de l'étape ii) dans un solvant organique ou ses mélanges et évaporation du solvant ou de ses mélanges de la solution ou de la suspension sous pression réduite pour obtenir une substance solide; iv). facultativement répétition de l'étape iii) une ou plusieurs fois; v). séchage de la substance solide obtenue aux étapes ii), iii) ou iv) pour produire la forme amorphe du Docétaxel. L'invention porte également: sur la forme amorphe du Docétaxel ainsi obtenue; et sur une composition comprenant la forme amorphe du Docétaxel et des excipients pharmaceutiquement acceptables, et servant à traiter des cancer d'origines diverses.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)