WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2008101886) N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/101886    International Application No.:    PCT/EP2008/051913
Publication Date: 28.08.2008 International Filing Date: 18.02.2008
IPC:
C07C 233/74 (2006.01), C07C 233/81 (2006.01), A61K 31/166 (2006.01), A61K 31/351 (2006.01), A61K 31/4402 (2006.01), A61K 31/4406 (2006.01), A61K 31/4465 (2006.01), C07D 211/22 (2006.01), C07D 211/96 (2006.01), C07D 213/30 (2006.01), C07D 213/71 (2006.01), A61P 3/00 (2006.01), C07D 309/06 (2006.01)
Applicants: HIGH POINT PHARMACEUTICALS, LLC [US/US]; 4170 Mendenhall Oaks Parkway, High Point, NC 27265 (US) (For All Designated States Except US).
EBDRUP, Søren [DK/DK]; (DK) (For US Only)
Inventors: EBDRUP, Søren; (DK)
Agent: BAILEY, Lindsey; Elkington and Fife LLP, Prospect House, 8 Pembroke Road, Sevenoaks, Kent TN13 1XR (GB)
Priority Data:
07102958.1 23.02.2007 EP
Title (EN) N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE
(FR) N-ADAMANTYL BENZAMIDES UTILISÉS EN TANT QU'INHIBITEURS DE LA 11-BÊTA-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE
Abstract: front page image
(EN)Novel substituted benzamide based inhibitors, their use in therapy, pharmaceutical compositions comprising the compounds, the use of said compounds in the manufacture of medicaments, and therapeutic methods comprising the administration of said compounds are described. The present compounds modulate the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, such as the metabolic syndrome.
(FR)L'invention concerne des nouveaux inhibiteurs à base de benzamide substitué, leur utilisation à des fins thérapeutiques, des compositions pharmaceutiques comprenant lesdits composés, l'utilisation desdits composés dans la fabrication de médicaments, et des méthodes thérapeutiques consistant à administrer lesdits composés. Les composés de l'invention modulent l'activité de la 11β-hydroxystéroïde déshydrogénase de type 1 (11βHSD1) et sont par conséquent utiles dans le traitement de maladies dans lesquelles ladite modulation est bénéfique, notamment pour le syndrome métabolique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)