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1. (WO2008101724) USE OF RIBOFLAVIN IN THE TREATMENT OF HYPERTENSION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/101724    International Application No.:    PCT/EP2008/001437
Publication Date: 28.08.2008 International Filing Date: 22.02.2008
Chapter 2 Demand Filed:    22.12.2008    
IPC:
A61K 31/525 (2006.01), A61P 9/12 (2006.01)
Applicants: UNIVERSITY OF ULSTER [GB/GB]; Cromore Road, Coleraine, County Londonderry BT52 1SA (GB) (For All Designated States Except US).
WESTERN HEALTH AND SOCIAL CARE TRUST [GB/GB]; Altnagelvin Hospital, Glenshane Road, Londonderry BT47 6SB (GB) (For All Designated States Except US).
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN [IE/IE]; College Green, Dublin 2 (IE) (For All Designated States Except US).
WARD, Mary [GB/GB]; (GB) (For US Only).
MCNULTY, Helene [GB/GB]; (GB) (For US Only).
HORIGAN, Geraldine [GB/GB]; (GB) (For US Only).
STRAIN, Sean [GB/GB]; (GB) (For US Only).
SCOTT, John [IE/IE]; (IE) (For US Only).
PURVIS, John [GB/GB]; (GB) (For US Only)
Inventors: WARD, Mary; (GB).
MCNULTY, Helene; (GB).
HORIGAN, Geraldine; (GB).
STRAIN, Sean; (GB).
SCOTT, John; (IE).
PURVIS, John; (GB)
Agent: JENNINGS, Tara; F.R. Kelly & Co., 27 Clyde Road, Ballsbridge, Dublin 4 (IE)
Priority Data:
0703514.0 23.02.2007 GB
Title (EN) USE OF RIBOFLAVIN IN THE TREATMENT OF HYPERTENSION
(FR) UTILISATION DE LA RIBOFLAVINE POUR LE TRAITEMENT DE L'HYPERTENSION
Abstract: front page image
(EN)The invention provides the use of riboflavin in the manufacture of a medicament for the treatment or prophylaxis of elevated blood pressure in a subject homozygous or heterozygous for the MTHFR C677T polymorphism. The invention also provides a pharmaceutical product for the treatment or prophylaxis of elevated blood pressure in a subject homozygous or heterozygous for the MTHFR C677T polymorphism, comprising a pharmaceutically effective amount of an anti-hypertensive agent and riboflavin, and the invention further provides a method of treatment of such a subject comprising the administration of riboflavin.
(FR)L'invention porte sur l'utilisation de riboflavine dans la fabrication d'un médicament pour le traitement ou la prophylaxie de l'hypertension chez un sujet homozygote ou hétérozygote pour le polymorphisme MTHFR C677T. L'invention porte également sur un produit pharmaceutique pour le traitement ou la prophylaxie de l'hypertension chez un sujet homozygote ou hétérozygote pour le polymorphisme MTHFR C677T, comprenant une quantité pharmaceutiquement efficace d'un agent hypotenseur et de riboflavine. L'invention porte en outre sur one méthode de traitement d'un tel sujet par administration de riboflavine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)