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Machine translation
1. (WO2008101202) N-17-ALKYLATED PRODRUGS OF OPIOIDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/101202    International Application No.:    PCT/US2008/054144
Publication Date: 21.08.2008 International Filing Date: 15.02.2008
IPC:
A61K 31/485 (2006.01), A61P 25/04 (2006.01), A61P 23/00 (2006.01), C07D 489/04 (2006.01)
Applicants: PHARMACOFORE, INC. [US/US]; 130 Lytton Avenue, Suite 100, Palo Alto, California 94301-1044 (US) (For All Designated States Except US).
JENKINS, Thomas, E. [US/US]; (US) (For US Only).
KOLESNIKOV, Aleksandr [US/US]; (US) (For US Only)
Inventors: JENKINS, Thomas, E.; (US).
KOLESNIKOV, Aleksandr; (US)
Agent: HARRIS, Robert, J.; P.O. Box 111098, Saint Paul, Minnesota 55111-1098 (US)
Priority Data:
60/901,795 16.02.2007 US
60/990,193 26.11.2007 US
Title (EN) N-17-ALKYLATED PRODRUGS OF OPIOIDS
(FR) PROMÉDICAMENTS D'OPIOÏDES
Abstract: front page image
(EN)Compounds of formula (II) R1R2R3N+-(C(R1a)(R2a))-Ar-Z-C(O)-Y-(C(R1)(R2))n-N-(R3)(R4) A-II, in which R1R2R3N+, R1a, R2a, Ar, Z, Y, R1, R2, n, R3, R4 and A- have the meanings given in the specification, are useful as prodrugs for opioids (Example 13).
(FR)Cette invention se rapporte à des composés de formule (II) R1R2R3N+-(C(R1a)(R2a))-Ar-Z-C(O)-Y-(C(R1)(R2))n-N-(R3)(R4) A-II, dans laquelle R1R2R3N+, R1a, R2a, Ar, Z, Y, R1, R2, n, R3, R4 et A- ont la signification donnée dans la description, qui sont utilisés comme promédicaments d'opioïdes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)