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Machine translation
1. (WO2008101179) USE OF SUCROSE TO SUPPRESS MANNITOL-INDUCED PROTEIN AGGREGATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/101179    International Application No.:    PCT/US2008/054115
Publication Date: 21.08.2008 International Filing Date: 15.02.2008
IPC:
A61K 9/10 (2006.01), A61K 47/26 (2006.01), A61K 38/00 (2006.01), A61K 39/395 (2006.01)
Applicants: WYETH [US/US]; Five Giralda Farms, Madison, NJ 07940 (US) (For All Designated States Except US).
SEK, David, C. [US/US]; (US) (For US Only).
WARNE, Nicholas, W. [US/US]; (US) (For US Only).
HO, Kin [US/US]; (US) (For US Only).
LUISI, Donna, L. [US/US]; (US) (For US Only).
KANTOR, Angela [US/US]; (US) (For US Only)
Inventors: SEK, David, C.; (US).
WARNE, Nicholas, W.; (US).
HO, Kin; (US).
LUISI, Donna, L.; (US).
KANTOR, Angela; (US)
Agent: BARNHARD, Elizabeth, M.; WYETH Patent Law Department Five Giralda Farms Madison, New Jersey 07940 (US)
Priority Data:
60/901,807 16.02.2007 US
Title (EN) USE OF SUCROSE TO SUPPRESS MANNITOL-INDUCED PROTEIN AGGREGATION
(FR) UTILISATION DE SACCHAROSE POUR SUPPRIMER UNE AGRÉGATION DE PROTÉINES PROVOQUÉE PAR DU MANNITOL
Abstract: front page image
(EN)The present invention provides a method for suppressing mannitol-induced protein aggregation by providing sucrose to a liquid formulation containing a protein. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and a combination of mannitol and sucrose such that the presence of sucrose suppresses mannitol-induced protein aggregation.
(FR)L'invention concerne un procédé de suppression d'une agrégation de protéines provoquée par du mannitol en ajoutant du saccharose à une formulation liquide contenant une protéine. L'invention concerne également des procédés de stockage et de préparation d'une formulation liquide contenant une protéine et une combinaison de mannitol et de saccharose, de sorte que la présence de saccharose supprime l'agrégation de protéines provoquée par du mannitol.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)