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1. (WO2008100508) PUUMALA VIRUS FULL-LENGTH M SEGMENT-BASED DNA VACCINES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/100508    International Application No.:    PCT/US2008/001847
Publication Date: 21.08.2008 International Filing Date: 12.02.2008
Chapter 2 Demand Filed:    11.12.2008    
IPC:
C07H 21/02 (2006.01), A61K 39/12 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, as represented by the Secretary of the Army, on behalf of the United States Army Medical Research Institute of Infectious Diseases [US/US]; 504 Scott Street Fort Detrick, MD 21702-5012 (US) (For All Designated States Except US).
HOOPER, Jay [US/US]; (US) (For US Only)
Inventors: HOOPER, Jay; (US)
Agent: ARWINE, Elizabeth; U.S. Army Medical Research And Materiel Command, Attn: MCMR-ZA-J, 504 Scott Street, Fort Detrick, MD 21702-5012 (US).
TITUS, Marlana; Nash & Titus, LLC, 6005 Riggs Road, Laytonsville, MD 20882 (US)
Priority Data:
60/901,414 12.02.2007 US
Title (EN) PUUMALA VIRUS FULL-LENGTH M SEGMENT-BASED DNA VACCINES
(FR) VACCINS DNA BASÉS SUR UN SEGMENT M DE PLEINE LONGUEUR DU VIRUS PUUMALA
Abstract: front page image
(EN)The invention contemplates a new synthetic, codon-optimized Puumala virus (PUUV) full-length M gene open reading frame (ORF) that encodes a unique consensus amino acid sequence. The PUUV ORF was cloned into a plasmid to form the first stable PUUV full-length M gene that elicits neutralizing antibodies. The gene can be engineered into a molecular vaccine system, and is useful to protect mammals against infection with Puumala virus.
(FR)L'invention concerne un nouveau cadre de lecture ouvert (ORF) synthétique du gène M de pleine longueur du virus Puumala à codon optimisé (PUUV) qui code une séquence d'acides aminés de consensus unique. L'ORF PUUV a été cloné en un plasmide pour former le premier gène M stable de pleine longueur du PUUV qui obtient des anticorps neutralisants. Le gène peut être conçu dans un système de vaccin moléculaire, et est utile pour protéger les mammifères contre une infection du virus Puumala.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)