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Machine translation
1. (WO2008100482) PEPTIDES THAT TARGET TO TUMOR BLOOD VESSELS OF LUNG CANCER AND APPLICATIONS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/100482    International Application No.:    PCT/US2008/001810
Publication Date: 21.08.2008 International Filing Date: 12.02.2008
IPC:
A61K 9/127 (2006.01), C07K 7/04 (2006.01), A61K 47/48 (2006.01), C12N 15/09 (2006.01)
Applicants: ACADEMIA SINICA [--/--]; No. 128, Sec. 2, Academia Road, Nagang District, Taipei City, 11529 (TW) (For All Designated States Except US).
NATIONAL TAIWAN UNIVERSITY [--/--]; No. 1, Sec. 4, Roosevelt Road, Da-an District, Taipei City, 10617 (TW) (For All Designated States Except US).
WU, Han-Chung [--/--]; (TW) (For US Only).
LIN, Chin-Tarng [US/--]; (TW) (For US Only).
LEE, Tong-Young [--/--]; (TW) (For US Only).
KUO, Szu-Yao [--/--]; (TW) (For US Only)
Inventors: WU, Han-Chung; (TW).
LIN, Chin-Tarng; (TW).
LEE, Tong-Young; (TW).
KUO, Szu-Yao; (TW)
Agent: GARRETT, Arthur, S.; Finnegan, Henderson, Farabow, Garrett & Dunner, L., L.P., 901 New York Avenue, NW, Washington, DC 20001-4413 (US)
Priority Data:
60/900,980 13.02.2007 US
60/901,086 14.02.2007 US
11/783,926 13.04.2007 US
Title (EN) PEPTIDES THAT TARGET TO TUMOR BLOOD VESSELS OF LUNG CANCER AND APPLICATIONS THEREOF
(FR) PEPTIDES CIBLANT DES VAISSEAUX SANGUINS TUMORAUX DU CANCER DU POUMON ET APPLICATIONS DE CEUX-CI
Abstract: front page image
(EN)The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target neovasculature and were identified by in vivo phage display. One such peptide, SP5-52, recognized the neovasculature of multiple tumors in SCED mice, but did not target normal blood vessels. This peptide also binds to blood vessels of human lung cancer biopsy specimens. Liposomes comprising SP5-52 and doxorubicin enhanced the efficacy of the drug against multiple human cancer xenografts in SCED mice.
(FR)L'invention concerne des acides nucléiques, des peptides et des anticorps pour une utilisation dans des applications comprenant un diagnostic et un traitement. Les peptides ciblent le système néovasculaire et sont identifiés par un affichage de bactériophage in vivo. Un de ces peptides, SP5-52, a reconnu le système néovasculaire de multiples tumeurs chez des souris SCED, mais n'a pas ciblé les vaisseaux sanguins normaux. Ce peptide se lie également aux vaisseaux sanguins des échantillons de biopsie du cancer du poumon humain. Les liposomes comprenant SP5-52 et la doxorubicine ont renforcé l'efficacité du médicament vis-à-vis des xénogreffes de cancer humain multiples chez des souris SCED. =
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)