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1. (WO2008100447) NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/100447    International Application No.:    PCT/US2008/001743
Publication Date: 21.08.2008 International Filing Date: 08.02.2008
IPC:
C07H 19/00 (2006.01), A61K 31/7052 (2006.01), C07F 9/547 (2006.01)
Applicants: GILEAD SCIENCES, INC. [US/US]; 333 Lakeside Drive, Foster City, CA 94404 (US) (For All Designated States Except US).
CHEN, James, M. [US/US]; (US) (For US Only).
HUANG, Alan, X. [CN/US]; (US) (For US Only).
MACKMAN, Richard, L. [GB/US]; (US) (For US Only).
PARRISH, Jay, P. [US/US]; (US) (For US Only).
PERRY, Jason, K. [US/US]; (US) (For US Only).
SAUNDERS, Oliver, L. [US/US]; (US) (For US Only).
SPERANDIO, David [CH/US]; (US) (For US Only)
Inventors: CHEN, James, M.; (US).
HUANG, Alan, X.; (US).
MACKMAN, Richard, L.; (US).
PARRISH, Jay, P.; (US).
PERRY, Jason, K.; (US).
SAUNDERS, Oliver, L.; (US).
SPERANDIO, David; (US)
Agent: WARD, John, S.; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US)
Priority Data:
60/900,692 09.02.2007 US
Title (EN) NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
(FR) ANALOGUES NUCLÉOSIDIQUES POUR TRAITEMENT ANTIVIRAL
Abstract: front page image
(EN)The invention provides unsaturated phosphonates of Formula I or a tautomer or pharmaceutically accepatble salt thereof, as described herein, as well as pharmaceutical compositions comprising the compounds, and therapeutic methods comprising administering the compounds. The compounds have anti-viral properties and are useful for treating viral infections (e.g. HCV) in animals (e.g. humans).
(FR)La présente invention concerne des phosphonates insaturés de formule (I) ou un tautomère ou un sel pharmaceutiquement acceptable de ceux-ci, ainsi que des compositions pharmaceutiques comportant les composés, et des procédés thérapeutiques comprenant l'administration des composés. Les composés présente des propriétés antivirales et sont utiles pour traiter des infections (par exemple, le VHC) chez des animaux (par exemple, des humains).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)