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1. (WO2008100376) TRUNCATION VARIANTS OF SIRT1 AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/100376    International Application No.:    PCT/US2008/001032
Publication Date: 21.08.2008 International Filing Date: 25.01.2008
IPC:
C12N 9/16 (2006.01)
Applicants: SIRTRIS PHARMACEUTICALS, INC. [US/US]; 200 Technology Square, Suite 300, Cambridge, MA 02139 (US) (For All Designated States Except US).
JIN, Lei [US/US]; (US) (For US Only).
KORKHIN, Yakov [IL/US]; (US) (For US Only)
Inventors: JIN, Lei; (US).
KORKHIN, Yakov; (US)
Agent: VINCENT, Matthew, P.; Ropes & Gray LLP, One International Place, Boston, MA 02110 (US)
Priority Data:
60/901,594 15.02.2007 US
Title (EN) TRUNCATION VARIANTS OF SIRT1 AND METHODS OF USE THEREOF
(FR) VARIANTS DE TRONCATURE DE SIRT1 ET PROCÉDÉS D'UTILISATION DE CEUX-CI
Abstract: front page image
(EN)Provided herein are novel sirtuin variants and methods of use thereof. The sirtuin variants may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising sirtuin variants, optionally in combination with other therapeutic agents.
(FR)La présente invention concerne de nouveaux variants de la sirtuine et des procédés d'utilisation de ceux-ci. Les variants de la sirtuine peuvent être utilisés pour faire augmenter la durée de vie d'une cellule, et traiter et/ou prévenir une vaste variété de maladies et de troubles, comprenant, par exemple, des maladies ou des troubles liés au vieillissement ou au stress, le diabète, l'obésité, des maladies neurodégénératives, une maladie cardiovasculaire, des troubles de la coagulation sanguine, une inflammation, un cancer, et/ou des bouffées congestives ainsi que des maladies ou des troubles qui pourraient bénéficier d'une activité mitochondriale accrue. La présente invention propose également des compositions comprenant des variants de la sirtuine, facultativement en combinaison avec d'autres agents thérapeutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)