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1. (WO2008100301) PLATINUM ANALOGS WITH BIS-NITRILE-CONTAINING LIGANDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/100301    International Application No.:    PCT/US2007/022893
Publication Date: 21.08.2008 International Filing Date: 30.10.2007
IPC:
A61K 31/275 (2006.01), A61K 31/382 (2006.01), C07F 15/00 (2006.01)
Applicants: BIONUMERIK PHARMACEUTICALS, INC. [US/US]; 8122 Datapoint Drive, Suite 1250, San Antonio, TX 78229 (US) (For All Designated States Except US).
CHEN, Xinghai [CN/US]; (US) (For US Only).
PETLURU, Pavankumar, N.V. [US/US]; (US) (For US Only).
HUANG, Qiuli [CN/US]; (US) (For US Only).
NARKUNAN, Kesavaram [US/US]; (US) (For US Only).
HAUSHEER, Frederick, H. [US/US]; (US) (For US Only)
Inventors: CHEN, Xinghai; (US).
PETLURU, Pavankumar, N.V.; (US).
HUANG, Qiuli; (US).
NARKUNAN, Kesavaram; (US).
HAUSHEER, Frederick, H.; (US)
Agent: WHITAKER, Scott, A.; BioNumerik Pharmaceuticals, Inc., 8122 Datapoint Drive, Suite 1250, San Antonio, TX 78229 (US)
Priority Data:
60/901,190 14.02.2007 US
Title (EN) PLATINUM ANALOGS WITH BIS-NITRILE-CONTAINING LIGANDS
(FR) ANALOGUES À BASE DE PLATINE AVEC DES LIGANDS CONTENANT DU BIS-NITRILE
Abstract: front page image
(EN)Disclosed herein are novel platinum-based analogs possessing two nitrile substituent groups (bis-nitrile) covalently-bonded to the platinum. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as quantitative in vitro IC50 data.
(FR)La présente invention concerne de nouveaux analogues à base de platine avec des ligands contenant deux groupes nitriles de substitution (bis-nitrile) en liaison covalente avec le platine. L'invention concerne également des schémas réactionnels pour la synthèse desdits complexes à base de platine, ainsi que de données IC50 quantitatives in vitro.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)