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1. (WO2008099913) THERAPEUTIC AGENT COMPRISING ANTIBODY CAPABLE OF SPECIFICALLY BINDING TO HUMAN HMGB-1 AS ACTIVE INGREDIENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/099913    International Application No.:    PCT/JP2008/052500
Publication Date: 21.08.2008 International Filing Date: 15.02.2008
IPC:
A61K 39/395 (2006.01), A61P 3/00 (2006.01), A61P 29/00 (2006.01), A61P 31/04 (2006.01), A61P 43/00 (2006.01), C07K 16/00 (2006.01)
Applicants: KUMAMOTO UNIVERSITY [JP/JP]; 39-1, Kurokami 2-chome, Kumamoto-shi, Kumamoto 8608555 (JP) (For All Designated States Except US).
KAGOSHIMA UNIVERSITY [JP/JP]; 21-24, Korimoto 1-chome, Kagoshima-shi, Kagoshima 8908580 (JP) (For All Designated States Except US).
SHINO-TEST CORPORATION [JP/JP]; 56, Kanda Jinbo-cho 1-chome, Chiyoda-ku, Tokyo 1018410 (JP) (For All Designated States Except US).
ANDO, Yukio [JP/JP]; (JP) (For US Only).
MARUYAMA, Ikuro [JP/JP]; (JP) (For US Only).
YAMADA, Shingo [JP/JP]; (JP) (For US Only)
Inventors: ANDO, Yukio; (JP).
MARUYAMA, Ikuro; (JP).
YAMADA, Shingo; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F 1-1-1, Oroshi-machi Tsuchiura-shi, Ibaraki 3000847 (JP)
Priority Data:
2007-034325 15.02.2007 JP
Title (EN) THERAPEUTIC AGENT COMPRISING ANTIBODY CAPABLE OF SPECIFICALLY BINDING TO HUMAN HMGB-1 AS ACTIVE INGREDIENT
(FR) AGENT THÉRAPEUTIQUE COMPORTANT UN ANTICORPS CAPABLE DE SE LIER SPÉCIFIQUEMENT À LA HMGB-1 HUMAINE COMME INGRÉDIENT ACTIF
(JA) ヒトHMGB-1に特異的に結合する抗体を有効成分として含有する治療剤
Abstract: front page image
(EN)Heretofore, it has been difficult to produce an antibody which can bind specifically to HMGB-1 but cannot bind to HMGB-2 and has high affinity. An antibody capable of reacting with HMGB-1 more strongly than with HMGB-2 is now successively produced by using a specific peptide as an antigen. It is also found that the antibody has a neutralizing activity against HMGB-1. The antibody is administered to a model animal of amyloidosis, and it is demonstrated that the antibody has a significant therapeutic effect on amyloidosis.
(FR)L'invention concerne la production d'un anticorps qui peut se lier spécifiquement à la HMGB-1 mais qui ne peut pas se lier à la HMGB-2 et qui présente une affinité élevée. Un anticorps capable de réagir avec la HMGB-1 plus fortement qu'avec la HMGB-2 est à présent produit avec succès en utilisant un peptide spécifique comme antigène. On a également découvert que l'anticorps possède une activité neutralisante contre la HMGB-1. L'anticorps est administré à un modèle animalier d'amyloïdose, et il est démontré que l'anticorps a un effet thérapeutique significatif sur l'amyloïdose.
(JA) 従来、HMGB-2に結合することなくHMGB-1に特異的に結合し、かつ親和性の高い抗体を得ることは容易ではなかった。このような中、本発明者らは、特定のペプチドを抗原として用いることによって、HMGB-2よりもHMGB-1に強く反応する抗体を取得することに成功した。また本発明者らは、上記抗体がHMGB-1に対して中和活性を有することを見出した。本発明者らは、上記抗体をアミロイドシスの疾患モデル動物に投与した結果、顕著な治療効果が得られることを実証することに成功した。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)