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1. (WO2008099906) THERAPEUTIC AGENT FOR PERIODONTAL DISEASE AND ALVEOLAR BONE LOSS DUE TO SURGERY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/099906    International Application No.:    PCT/JP2008/052482
Publication Date: 21.08.2008 International Filing Date: 15.02.2008
IPC:
A61K 48/00 (2006.01), A61K 31/713 (2006.01), A61K 45/00 (2006.01), A61K 47/42 (2006.01), A61P 1/02 (2006.01), A61P 19/08 (2006.01), A61P 29/00 (2006.01)
Applicants: ANGES MG, INC. [JP/JP]; 7-15, Saitoasagi 7-chome, Ibaraki-shi, Osaka 5670085 (JP) (For All Designated States Except US).
MORISHITA, Ryuichi [JP/JP]; (JP) (For US Only).
NAKAGAMI, Hironori [JP/JP]; (JP) (For US Only).
SHIMIZU, Hideo [JP/JP]; (JP) (For US Only)
Inventors: MORISHITA, Ryuichi; (JP).
NAKAGAMI, Hironori; (JP).
SHIMIZU, Hideo; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F, 1-1-1, Oroshi-machi, Tsuchiura-shi, Ibaraki 3000847 (JP)
Priority Data:
2007-036135 16.02.2007 JP
Title (EN) THERAPEUTIC AGENT FOR PERIODONTAL DISEASE AND ALVEOLAR BONE LOSS DUE TO SURGERY
(FR) AGENT THÉRAPEUTIQUE POUR MALADIE PARODONTALE ET PERTE OSSEUSE ALVÉOLAIRE EN RAISON D'UNE OPÉRATION CHIRURGICALE
(JA) 歯周病、及び外科手術による歯槽骨欠損の治療剤
Abstract: front page image
(EN)According to the invention, it was revealed that by inhibiting transcriptional activation of NF-κB, absorption of alveolar bone is inhibited in a model of periodontal disease, and repair of alveolar bone is promoted in a model of bone loss due to periodontal disease. Accordingly, the invention provides a therapeutic, prophylactic and improving agent for periodontal disease and alveolar bone loss due to surgery or the like containing an active ingredient for inhibiting transcriptional activation of NF-κB such as NF-κB decoy.
(FR)L'invention concerne l'inhibition de l'absorption d'os alvéolaire, par l'inhibition de l'activation transcriptionnelle de NF-kB, dans un modèle de maladie parodontale et la réparation d'os alvéolaire qui est favorisée dans un modèle de perte osseuse en raison d'une maladie parodontale. Par conséquent, l'invention propose un agent thérapeutique, prophylactique et d'amélioration pour une maladie parodontale et une perte osseuse alvéolaire en raison d'une opération chirurgicale ou d'une opération similaire contenant un ingrédient actif pour inhiber l'activation transcriptionnelle de NF-kB telle qu'un leurre de NF-kB.
(JA) 本発明により、NFκBによる転写活性化を抑制することにより、歯周病モデルにおいて歯槽骨の吸収が抑制され、歯周病骨欠損モデルにおいて歯槽骨の修復を促進されることが明らかとなった。そこで、本発明は、NFκBデコイ等のNFκBの転写活性を抑制する有効成分を含有する歯周病、及び外科手術等による歯槽骨欠損の治療、予防、及び改善剤を提供するものである。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)