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Machine translation
1. (WO2008099175) CAMP DEPENDENT INDUCTION OF AUTOPHAGY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/099175    International Application No.:    PCT/GB2008/000501
Publication Date: 21.08.2008 International Filing Date: 14.02.2008
IPC:
A61K 31/00 (2006.01), A61K 31/138 (2006.01), A61K 31/277 (2006.01), A61K 31/415 (2006.01), A61K 31/506 (2006.01), A61P 25/28 (2006.01), A61P 31/00 (2006.01), A61K 31/436 (2006.01)
Applicants: CAMBRIDGE ENTERPRISE LIMITED [GB/GB]; The Old Schools, Trinity Lane, Cambridge Cambridgeshire CB2 1TN (GB) (For All Designated States Except US).
RUBINSZTEIN, David [GB/GB]; (GB) (For US Only).
SARKAR, Sovan [IN/GB]; (GB) (For US Only).
WILLIAMS, Andrea [GB/GB]; (GB) (For US Only)
Inventors: RUBINSZTEIN, David; (GB).
SARKAR, Sovan; (GB).
WILLIAMS, Andrea; (GB)
Agent: SUTCLIFFE, Nicholas; Mewburn Ellis LLP, 33 Gutter Lane, London EC2V 8AS (GB)
Priority Data:
0702972.1 15.02.2007 GB
Title (EN) CAMP DEPENDENT INDUCTION OF AUTOPHAGY
(FR) INDUCTION D'AUTOPHAGIE DÉPENDANTE DE L'AMP CYCLIQUE
Abstract: front page image
(EN)The present invention relates to the induction of autophagy via mTOR independent pathways which modulate intracytosolic cAMP levels. In some embodiments, autophagy may be induced in a cell by reducing intracytosolic cAMP levels, for example using a cAMP antagonist, such as clonidine. This may be useful, for example in the treatment of neurodegenerative disorders or pathogen infections.
(FR)La présente invention concerne l'induction d'autophagie par des trajectoires indépendantes du mTOR qui modulent des niveaux d'AMP cyclique intracytosolique. Dans certains modes de réalisation, l'autophagie peut être induite dans une cellule en réduisant les niveaux d'AMP cyclique intracytosolique, par exemple en utilisant un antagoniste d'AMP cyclique, tel que la clonidine. Cela peut s'avérer utile par exemple dans le traitement de troubles neurodégénératifs ou d'infections pathogènes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)