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1. (WO2008099019) 6-HYDROXY-DIBENZODIAZEPINONES USEFUL AS HEPATITIS C VIRUS INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/099019    International Application No.:    PCT/EP2008/051902
Publication Date: 21.08.2008 International Filing Date: 15.02.2008
IPC:
C07D 243/38 (2006.01), C07D 401/04 (2006.01), C07D 401/06 (2006.01), C07D 403/06 (2006.01), C07D 403/12 (2006.01), C07D 407/04 (2006.01), C07D 407/06 (2006.01), C07D 407/14 (2006.01), C07D 409/04 (2006.01), C07D 413/06 (2006.01), C07D 417/06 (2006.01), C07D 513/04 (2006.01), A61K 31/5513 (2006.01), A61P 1/16 (2006.01)
Applicants: TIBOTEC PHARMACEUTICALS LTD. [IE/IE]; Eastgate Village, Eastgate, Little Island, Co Cork (IE) (For All Designated States Except US).
RABOISSON, Pierre Jean-Marie Bernard [FR/BE]; (BE) (For US Only).
MC GOWAN, David Craig [US/BE]; (BE) (For US Only).
VANDYCK, Koen [BE/BE]; (BE) (For US Only).
VENDEVILLE, Sandrine Marie Helene [FR/BE]; (BE) (For US Only).
BONFANTI, Jean-François [FR/FR]; (FR) (For US Only).
VAN DEN BROECK, Walter Marcel Mathilde [BE/BE]; (BE) (For US Only).
NYANGUILE, Origène [CH/BE]; (BE) (For US Only).
AMSSOMS, Katie Ingrid Eduard [BE/BE]; (BE) (For US Only).
HU, Lili [NL/BE]; (BE) (For US Only).
BOUTTON, Carlo Willy Maurice [BE/BE]; (BE) (For US Only).
TAHRI, Abdellah [BE/BE]; (BE) (For US Only).
LAST, Stefaan Julien [BE/BE]; (BE) (For US Only).
ROMBAUTS, Klara [BE/BE]; (BE) (For US Only).
REBSTOCK, Anne-Sophie Helene Marie [FR/FR]; (FR) (For US Only).
FORTIN, Jérôme Michel Claude [FR/FR]; (FR) (For US Only).
MULLER, Philippe [FR/FR]; (FR) (For US Only)
Inventors: RABOISSON, Pierre Jean-Marie Bernard; (BE).
MC GOWAN, David Craig; (BE).
VANDYCK, Koen; (BE).
VENDEVILLE, Sandrine Marie Helene; (BE).
BONFANTI, Jean-François; (FR).
VAN DEN BROECK, Walter Marcel Mathilde; (BE).
NYANGUILE, Origène; (BE).
AMSSOMS, Katie Ingrid Eduard; (BE).
HU, Lili; (BE).
BOUTTON, Carlo Willy Maurice; (BE).
TAHRI, Abdellah; (BE).
LAST, Stefaan Julien; (BE).
ROMBAUTS, Klara; (BE).
REBSTOCK, Anne-Sophie Helene Marie; (FR).
FORTIN, Jérôme Michel Claude; (FR).
MULLER, Philippe; (FR)
Agent: DAELEMANS, Frank; Tibotec-Virco Comm. VA, J & J Patent Law Department, Generaal De Wittelaan L 11B 3, B-2800 Mechelen (BE)
Priority Data:
07102519.1 16.02.2007 EP
Title (EN) 6-HYDROXY-DIBENZODIAZEPINONES USEFUL AS HEPATITIS C VIRUS INHIBITORS
(FR) 6-HYDROXY-DIBENZODIAZÉPINONES UTILES COMME INHIBITEURS DU VIRUS DE L'HÉPATITE C
Abstract: front page image
(EN)Inhibitors of HCV replication of formula (I) the stereoisomers, prodrugs, tautomers, racemics, salts, hydrates or solvates thereof wherein R1, R2; R3; R4a and R4b have the meaning defined in the claims.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.
(FR)L'invention porte sur des inhibiteurs de réplication du VHC de formule (I), sur les stéréoisomères, les promédicaments, les tautomères, les racémiques, les sels, les hydrates ou les solvates de ceux-ci. Dans la formule, R1, R2 ; R3 ; R4a et R4b ont la signification définie dans les revendications. La présente invention porte également sur des procédés pour préparer lesdits composés, les compositions pharmaceutiques les contenant et sur leur utilisation en thérapie du VHC.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)