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1. (WO2008098308) AGENTS AND METHODS FOR TREATMENT OF CELL PROLIFERATIVE DISEASES AND CONDITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/098308    International Application No.:    PCT/AU2008/000203
Publication Date: 21.08.2008 International Filing Date: 15.02.2008
IPC:
A61K 38/16 (2006.01), A61P 35/00 (2006.01)
Applicants: NEWCASTLE INNOVATION LIMITED [AU/AU]; Industry Development Centre, University Drive, Callaghan, NSW 2308 (AU) (For All Designated States Except US).
CHILDREN'S MEDICAL RESEARCH INSTITUTE [AU/AU]; 214 Hawkesbury Road, Westmead, NSW 2145 (AU) (For All Designated States Except US).
MCCLUSKEY, Adam [AU/AU]; (AU) (For US Only).
ROBINSON, Phillip, J. [AU/AU]; (AU) (For US Only).
FABBRO, Megan [AU/AU]; (AU) (For US Only)
Inventors: MCCLUSKEY, Adam; (AU).
ROBINSON, Phillip, J.; (AU).
FABBRO, Megan; (AU)
Agent: ADAMS PLUCK; Suite 3, Level 1, 20 George Street, Hornsby, NSW 2077 (AU)
Priority Data:
2007900749 15.02.2007 AU
2007900863 21.02.2007 AU
Title (EN) AGENTS AND METHODS FOR TREATMENT OF CELL PROLIFERATIVE DISEASES AND CONDITIONS
(FR) AGENTS ET PROCÉDÉS POUR LE TRAITEMENT DE MALADIES ET DE CONDITIONS PRÉSENTANT DES CELLULES PROLIFÉRATIVES
Abstract: front page image
(EN)There are provided phospho-mimetics of a region of DynII including S764 or a phosphorylatable amino acid in a homologous position. The phospho-mimetics find use in inhibiting cytokinesis and have application in prophylaxis or treatment of cell proliferative diseases and conditions such as cancer. There is also provided assays for screening for inhibitors of cytokinesis.
(FR)La présente invention concerne des phosphomimétiques d'une région de DynII comportant du S764 ou un acide aminé phosphorylable dans une position homologue. Les phosphomimétiques sont utilisés dans l'inhibition d'une cytocinèse et sont appliqués dans la prophylaxie ou le traitement de maladies et de conditions présentant des cellules prolifératives telles que le cancer. La présente invention concerne également des dosages pour diaphragmer les inhibiteurs de la cytocinèse.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)