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Pub. No.:    WO/2008/098277    International Application No.:    PCT/AT2008/000049
Publication Date: 21.08.2008 International Filing Date: 13.02.2008
G01N 33/68 (2006.01)
Applicants: UNIVERSITÄT SALZBURG [AT/AT]; Kapitelgasse 6, A-5020 Salzburg (AT) (For All Designated States Except US).
THALHAMER, Josef [AT/AT]; (AT) (For US Only).
HARTL, Arnulf [AT/AT]; (AT) (For US Only).
SIPPL, Manfred [AT/AT]; (AT) (For US Only).
LACKNER, Peter [AT/AT]; (AT) (For US Only).
FERREIRA-BRIZA, Fatima [AT/AT]; (AT) (For US Only).
THALHAMER, Theresa [AT/AT]; (AT) (For US Only).
STUTZ, Hanno [AT/DE]; (DE) (For US Only)
Inventors: THALHAMER, Josef; (AT).
HARTL, Arnulf; (AT).
SIPPL, Manfred; (AT).
LACKNER, Peter; (AT).
THALHAMER, Theresa; (AT).
STUTZ, Hanno; (DE)
Agent: SONN & PARTNER; Riemergasse 14, A-1010 Vienna (AT)
Priority Data:
A 231/2007 14.02.2007 AT
A 261/2007 20.02.2007 AT
Abstract: front page image
(EN)The present invention relates to a method for identifying a hypoallergenic derivative of a wild-type allergen comprising: determining the three-dimensional structure of a wild-type allergen; introducing at least one point mutation into said wild-type allergen, thereby obtaining a mutated allergen; identifying a hypoallergenic derivative of said wild-type allergen by detecting a destabilisation or change of the three-dimensional structure of the mutated allergen compared to the wild-type allergen by determining energy differences between the wild-type allergen and the mutant allergen expressed as a Z-score.
(FR)La présente invention concerne un procédé d'identification d'un dérivé hypoallergénique d'un allergène de type sauvage, consistant à déterminer la structure tridimensionnelle d'un allergène de type sauvage; à introduire au moins une mutation ponctuelle dans ledit allergène de type sauvage, obtenant ainsi un allergène mutant; à identifier un dérivé hypoallergénique dudit allergène de type sauvage par détection d'une déstabilisation ou d'un changement de la structure tridimensionnelle de l'allergène mutant par rapport à l'allergène de type sauvage par détermination des différences énergétiques entre l'allergène de type sauvage et l'allergène mutant pour obtenir un résultat Z.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)