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Machine translation
1. (WO2008098244) NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/098244    International Application No.:    PCT/US2008/053581
Publication Date: 14.08.2008 International Filing Date: 11.02.2008
IPC:
C07C 311/08 (2006.01), C07C 233/29 (2006.01), C07C 235/56 (2006.01)
Applicants: METABASIS THERAPEUTICS, INC. [US/US]; 11119 North Torrey Pines Road, La Jolla, CA 92037 (US) (For All Designated States Except US).
GOMEZ-GALENO, Jorge, E. [US/US]; (US) (For US Only).
REDDY, Raja, K. [US/US]; (US) (For US Only).
VAN POELJE, Paul, D. [NL/US]; (US) (For US Only).
LEMUS, Robert, Huerta [US/US]; (US) (For US Only).
NGUYEN, Thanh, Huu [US/US]; (US) (For US Only).
GROTE, Matthew, P. [US/US]; (US) (For US Only).
DANG, Qun [US/US]; (US) (For US Only).
HECKER, Scott, J. [US/US]; (US) (For US Only).
MALI, Venkat, Reddy [IN/US]; (US) (For US Only).
CHEN, Mingwei [CN/US]; (US) (For US Only).
SUN, Zhili [US/US]; (US) (For US Only).
BOYER, Serge, Henri [FR/US]; (US) (For US Only).
LI, Haiqing [CN/US]; (US) (For US Only).
CRAIGO, William [US/US]; (US) (For US Only)
Inventors: GOMEZ-GALENO, Jorge, E.; (US).
REDDY, Raja, K.; (US).
VAN POELJE, Paul, D.; (US).
LEMUS, Robert, Huerta; (US).
NGUYEN, Thanh, Huu; (US).
GROTE, Matthew, P.; (US).
DANG, Qun; (US).
HECKER, Scott, J.; (US).
MALI, Venkat, Reddy; (US).
CHEN, Mingwei; (US).
SUN, Zhili; (US).
BOYER, Serge, Henri; (US).
LI, Haiqing; (US).
CRAIGO, William; (US)
Agent: RIEGER, Dale, L.; Jones Day, 12265 El Camino Real, Suite 200, San Diego, CA 92130 (US)
Priority Data:
60/889,183 09.02.2007 US
60/989,287 20.11.2007 US
Title (EN) NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR
(FR) NOUVEAUX ANTAGONISTES DU RÉCEPTEUR AU GLUCAGON
Abstract: front page image
(EN)The present invention provides for novel compounds of Formula (I) and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistence and hyperglycemia. The present invention also provides for processes of making the compounds of Formula I, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.
(FR)La présente invention propose de nouveaux composés de formule (I) et les sels et co-cristaux pharmaceutiquement acceptables de ceux-ci qui ont une activité antagoniste ou agoniste inverse du récepteur au glucagon. La présente invention propose en outre des compositions pharmaceutiques les comprenant ainsi que des procédés de traitement, de prévention, de retardement de la durée avant la déclaration ou de réduction du risque de développement ou de progression d'une maladie ou d'une condition pour laquelle un ou plusieurs antagonistes du récepteur au glucagon est indiqué, y compris le diabète de type I et II, l'insulinorésistance et l'hyperglycémie. La présente invention propose également des procédés de préparation des composés de formule I, y compris les sels et co-cristaux de ceux-ci, et des compositions pharmaceutiques les comprenant.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)