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1. (WO2008098199) SEQUENCES FOR FK228 BIOSYNTNESIS AND METHODS OF SYNTHESIZING FK228 AND FK228 ANALOGS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/098199    International Application No.:    PCT/US2008/053473
Publication Date: 14.08.2008 International Filing Date: 08.02.2008
IPC:
C12N 15/52 (2006.01), C12N 1/21 (2006.01), C12P 17/18 (2006.01), C07K 11/02 (2006.01)
Applicants: UWM RESEARCH FOUNDATION, INC. [US/US]; 3230 East Kenwood Boulevard, UWM Alumni House, Milwaukee, Wisconsin 53211 (US) (For All Designated States Except US).
CHENG, Yi-qiang [CN/US]; (US) (For US Only)
Inventors: CHENG, Yi-qiang; (US)
Agent: FAHRLANDER, Jill, A.; Michael Best & Friedrich Llp, 100 East Wisconsin Avenue, Suite 3300, Milwaukee, WI 53202-4108 (US)
Priority Data:
60/888,851 08.02.2007 US
Title (EN) SEQUENCES FOR FK228 BIOSYNTNESIS AND METHODS OF SYNTHESIZING FK228 AND FK228 ANALOGS
(FR) SÉQUENCES UTILISABLES POUR LA BIOSYNTHÈSE DE FK228 ET PROCÉDÉS DE SYNTHÈSE DE FK228 ET D'ANALOGUES DE FK228
Abstract: front page image
(EN)Polynucleotides encoding the polypeptides involved in biosynthesis of FK 228 and those involved in synthesis of a novel FK228 analog, thailandepsin are disclosed herein. Also provided are methods of making FK228, thailandepsin and analogs of these molecules and methods of using these FK228 analogs. Chromobacterium and Burkholderia gene inactivation mutants are provided. Methods of forming a disulfide bond in a chemical are also disclosed.
(FR)La présente invention concerne des polynucléotides codant pour les polypeptides impliqués dans la biosynthèse de FK228, ainsi que des polypeptides impliqués dans la synthèse d'un analogue inédit de FK228, la thaïlandepsine. Elle concerne également des procédés de fabrication de FK228, de la thaïlandepsine et d'analogues de ces molécules, ainsi que des procédés d'utilisation de ces analogues de FK228. Elle concerne, encore, des mutants permettant l'inactivation du gène de Chromobactérium et de Burkholderia. Enfin, elle concerne des procédés de formation d'un pont disulfure dans un produit chimique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)