WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2008098159) GENETIC MARKER FOR RISK OF CARDIOVASCULAR DISORDER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/098159    International Application No.:    PCT/US2008/053404
Publication Date: 14.08.2008 International Filing Date: 08.02.2008
IPC:
C07H 21/02 (2006.01), C12Q 1/68 (2006.01), C12P 19/34 (2006.01)
Applicants: THE CLEVELAND CLINIC FOUNDATION [US/US]; 9500 Euclid Avenue, Cleveland, OH 44195 (US) (For All Designated States Except US).
AGAH, Ramtin [US/US]; (US) (For US Only).
MURUGESAN, Gurunathan [US/US]; (US) (For US Only).
KOTTKE-MARCHANT, Kandice [US/US]; (US) (For US Only).
ELLIS, Stephen [US/US]; (US) (For US Only).
TUBBS, Raymond [US/US]; (US) (For US Only)
Inventors: AGAH, Ramtin; (US).
MURUGESAN, Gurunathan; (US).
KOTTKE-MARCHANT, Kandice; (US).
ELLIS, Stephen; (US).
TUBBS, Raymond; (US)
Agent: SUTKUS, Richard, A.; Tarolli, Sundheim, Covell & Tummino L.L.P, 1300 East Ninth Street, Suite 1700, Cleveland, OH 44114 (US)
Priority Data:
60/888,957 09.02.2007 US
Title (EN) GENETIC MARKER FOR RISK OF CARDIOVASCULAR DISORDER
(FR) MARQUEUR GÉNÉTIQUE POUR LE RISQUE DE TROUBLE CARDIOVASCULAIRE
Abstract: front page image
(EN)A method of identifying a subject at increased risk of developing cardiovascular disorder includes obtaining a biological sample containing a nucleic acid from the subject and determining the presence of at least one polymorphism in at least one of a TGFB 1 gene, TGFB R2 gene, or TLR2 gene. The presence of the at least one polymorphism is indicative of an increased risk of a cardiovascular disorder.
(FR)La présente invention concerne un procédé consistant à identifier un sujet présentant un risque important de trouble cardiovasculaire croissant, qui comporte les étapes consistant à obtenir un échantillon biologique contenant un acide nucléique depuis le sujet et déterminer la présence d'au moins un polymorphisme dans au moins un gène TGFB 1, un gène TGFB R2 ou un gène TLR2. La présence d'un ou de polymorphisme indique un risque croissant d'un trouble cardiovasculaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)