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1. (WO2008098158) LOCAL ANTI-INFECTIVE AGENT FOR TREATMENT OF NAIL FUNGAL INFECTIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/098158    International Application No.:    PCT/US2008/053397
Publication Date: 14.08.2008 International Filing Date: 08.02.2008
IPC:
A61K 8/00 (2006.01), A61K 8/18 (2006.01)
Applicants: DERMWORX, INCORPORATED [US/US]; 934 S. Southlake Drive, Hollywood, FL 33019 (US) (For All Designated States Except US).
COHEN, David, M. [US/US]; (US) (For US Only).
COOPER, Eugene, R. [US/US]; (US) (For US Only)
Inventors: COHEN, David, M.; (US).
COOPER, Eugene, R.; (US)
Agent: VINCENT, Matthew, P.; Ropes & Gray LLP, One International Place, Boston, MA 02110 (US)
Priority Data:
60/888,825 08.02.2007 US
Title (EN) LOCAL ANTI-INFECTIVE AGENT FOR TREATMENT OF NAIL FUNGAL INFECTIONS
(FR) AGENT ANTI-INFECTIEUX LOCAL DESTINÉ AU TRAITEMENT DES INFECTIONS FONGIQUES DES ONGLES
Abstract: front page image
(EN)A topical composition for treating nail fungal infections that utilizes an acidic antifungal agent with a molecular weight no greater than 170 Daltons in a formulation having a pH less than or equal to the pKa of the acidic antifungal agent plus one. Possible antifungal agents include omadine, octanoic acid, sorbic acid, hexanoic acid, and benzoic acid. The antifungal agent can be combined with a delivery system such as a lacquer, a gel, a patch, or a hydrating system. A second therapeutic agent such as a 5-fluorocystine or terbinafme can be included.
(FR)La présente invention concerne des compositions topiques destinées au traitement des infections fongiques des ongles. Lesdites compositions utilisent un agent antifongique acide avec un poids moléculaire n'excédant pas 170 daltons, dans une formulation présentant un pH inférieur ou égal au pKa de l'agent antifongique acide plus un. Les agents antifongiques potentiels incluent l'omadine, l'acide octanoïque, l'acide sorbique, l'acide hexanoïque et l'acide benzoïque. L'agent antifongique peut être associé à un système d'application tel qu'un vernis, un gel, un timbre transdermique ou un système hydratant. Un second agent thérapeutique tel que la 5-fluorocytosine ou la terbinafine peut être inclus.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)