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1. (WO2008098115) OPTIMIZED IGF-1R ANTIBODIES AND METHODS OF USING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/098115    International Application No.:    PCT/US2008/053297
Publication Date: 14.08.2008 International Filing Date: 07.02.2008
IPC:
A61K 39/395 (2006.01), A61P 35/00 (2006.01), C07K 16/28 (2006.01)
Applicants: XENCOR, INC. [US/US]; 111 West Lemon Avenue, Monrovia, California 91016 (US) (For All Designated States Except US).
CHAMBERLAIN, Aaron K. [US/US]; (US) (For US Only).
DANG, Wei [US/US]; (US) (For US Only).
LAZAR, Gregory Alan [US/US]; (US) (For US Only)
Inventors: CHAMBERLAIN, Aaron K.; (US).
DANG, Wei; (US).
LAZAR, Gregory Alan; (US)
Agent: WORRALL, Timothy A.; 370 17th Street, Suite 4700, Denver, Colorado 80202 (US)
Priority Data:
60/888,744 07.02.2007 US
Title (EN) OPTIMIZED IGF-1R ANTIBODIES AND METHODS OF USING THE SAME
(FR) ANTI-CORPS IGF-1R OPTIMISÉS ET PROCÉDÉS UTILISANT CEUX-CI
Abstract: front page image
(EN)The present application describes antibodies that target IGF-1R, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification improves the sequence of said antibody and/or alters the effector function of said antibody. Also disclosed are methods of using the antibodies of the invention.
(FR)La présente invention concerne des anti-corps qui visent l'IGF-1R. Les anti-corps comprennent au moins une modification par rapport à un anti-corps parent qui améliore la séquence dudit anti-corps et/ou modifie la fonction effectrice dudit anti-corps. Elle décrit également des procédés consistant à utiliser les anti-corps de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)