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1. (WO2008097991) PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/097991    International Application No.:    PCT/US2008/053075
Publication Date: 14.08.2008 International Filing Date: 05.02.2008
IPC:
C07D 471/04 (2006.01), A61K 31/505 (2006.01), A61P 25/00 (2006.01)
Applicants: XENON PHARMACEUTICALS INC. [CA/CA]; 3650 Gilmore Way, Burnaby, British Columbia V5G 4W8 (CA) (For All Designated States Except US).
LIU, Shifeng [CA/CA]; (CA) (For US Only).
FU, Jianmin [US/CA]; (CA) (For US Only).
KAMBOJ, Rajender [CA/CA]; (CA) (For US Only).
JIA, Qi [CA/CA]; (CA) (For US Only).
WOOD, Mark [CA/CA]; (CA) (For US Only).
CHOWDHURY, Sultan [CA/CA]; (CA) (For US Only).
SUN, Jianyu [CA/CA]; (CA) (For US Only)
Inventors: LIU, Shifeng; (CA).
FU, Jianmin; (CA).
KAMBOJ, Rajender; (CA).
JIA, Qi; (CA).
WOOD, Mark; (CA).
CHOWDHURY, Sultan; (CA).
SUN, Jianyu; (CA)
Agent: ROTH, Carol, J.; Seed Intellectual Property Law Group PLLC, Suite 5400, 701 Fifth Avenue, Seattle, Washington 98104 (US)
Priority Data:
60/888,253 05.02.2007 US
60/912,122 16.04.2007 US
Title (EN) PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS
(FR) COMPOSÉS DE PYRIDOPYRIMIDINONE UTILES DANS LE TRAITEMENT DE MALADIES OU D'AFFECTIONS VÉHICULÉES PAR LES CANAUX SODIQUES
Abstract: front page image
(EN)This invention is directed to pyridopyrimidinone compounds of formula (I): wherein n, R1, R2 and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
(FR)L'invention concerne des composés de pyridopyrimidinone de formule (I) : dans laquelle n, R1, R2 et R3 sont tels que définis ici, comme un stéréo-isomère, un énantiomère, un tautomère de ceux-ci ou des mélanges de ceux-ci; ou un sel, solvate ou promédicament pharmaceutiquement acceptable de ceux-ci, utile dans le traitement et/ou la prévention de maladies ou d'affections véhiculées par les canaux sodiques, telles que la douleur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)