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Machine translation
1. (WO2008097844) METHODS AND COMPOSITIONS RELATING TO THE REGULATION OF APOPTOSIS BY MUC1 AND BH3- CONTAINING PROAPOPTOTIC PROTEINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/097844    International Application No.:    PCT/US2008/052799
Publication Date: 14.08.2008 International Filing Date: 01.02.2008
IPC:
G01N 33/53 (2006.01), C07K 14/435 (2006.01)
Applicants: DANA -FARBER CANCER INSTITUTE, INC. [US/US]; 44 Binney Street, Boston, MA 02115 (US) (For All Designated States Except US).
KUFE, Donald, W. [US/US]; (US) (For US Only)
Inventors: KUFE, Donald, W.; (US)
Agent: DE LA PAZ, Monica, A.; Fulbright & Jaworski L.l.p., 600 Congress Avenue, Suite 2400, Austin, TX 78701 (US)
Priority Data:
60/888,000 02.02.2007 US
Title (EN) METHODS AND COMPOSITIONS RELATING TO THE REGULATION OF APOPTOSIS BY MUC1 AND BH3- CONTAINING PROAPOPTOTIC PROTEINS
(FR) MÉTHODES ET COMPOSITIONS ASSOCIÉES À LA RÉGULATION DE L'APOPTOSE PAR DES PROTÉINES MUC1 ET DES PROTÉINES PRO-APOPTOTIQUES CONTENANT SEULEMENT LE DOMAINE BH3
Abstract: front page image
(EN)This invention relates to regulation of cell signaling, cell growth, and more particularly to the regulation of cancer or immune cell growth. The invention provides methods of inhibiting interactions between MUC1 and BH3 -containing proapoptotic proteins, methods of inhibiting MUC1 expression, and methods of promoting apoptosis. Also provided are screening methods for compounds that inhibit interactions between MUC1 and BH3 -containing proapoptotic proteins and pharmaceutical compositions of the same.
(FR)L'invention concerne la régulation de la signalisation cellulaire, de la croissance cellulaire, et plus particulièrement la régulation du cancer ou de la croissance de cellules immunitaires. L'invention concerne des méthodes d'inhibition d'interactions entre des protéines MUC1 et des protéines pro-apoptotiques contenant seulement le domaine BH3, des méthodes d'inhibition de l'expression de protéines MUC1, ainsi que des méthodes de stimulation de l'apoptose. L'invention concerne également des méthodes de criblage de composés qui inhibent les interactions entre des protéines MUC1 et des protéines pro-apoptotiques contenant seulement le domaine BH3 ainsi que des compositions pharmaceutiques desdits composés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)