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Machine translation
1. (WO2008097673) COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/097673    International Application No.:    PCT/US2008/050289
Publication Date: 14.08.2008 International Filing Date: 04.01.2008
IPC:
A61K 31/423 (2006.01), A61K 31/454 (2006.01), A61K 31/4545 (2006.01), C07K 5/06 (2006.01), C07K 5/08 (2006.01), A61P 11/00 (2006.01)
Applicants: IRM LLC [US/--]; 131 Front Street, P.O. Box HM 2899, Hamilton, HM LX (BM) (For All Designated States Except US).
TULLY, David, C. [US/US]; (US) (For US Only).
CHATTERJEE, Arnab, K. [US/US]; (US) (For US Only).
VIDAL, Agnes [FR/US]; (US) (For US Only).
BURSULAYA, Badry [RU/US]; (US) (For US Only)
Inventors: TULLY, David, C.; (US).
CHATTERJEE, Arnab, K.; (US).
VIDAL, Agnes; (US).
BURSULAYA, Badry; (US)
Agent: TONGCO WU, Emily; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 (US)
Priority Data:
60/889,008 09.02.2007 US
Title (EN) COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS
(FR) COMPOSÉS ET COMPOSITIONS EN TANT QU'INHIBITEURS DE LA PROTÉASE ACTIVATRICE DE CANAUX
Abstract: front page image
(EN)The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.
(FR)La présente invention concerne des composés et leurs compositions pharmaceutiques, qui servent à moduler les protéases activatrices de canaux, et des procédés destinés à l'utilisation de tels composés afin de traiter, améliorer ou prévenir un état associé à une protéase activatrice de canaux, comprenant mais sans s'y limiter la prostasine, les PRSS22, TMPRSS11 (TMPRSS11B, TMPRSS11E, par exemple), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), la matriptase (MTSP-1), CAP2, CAP3, la trypsine, la cathepsine A ou l'élastase neutrophile.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)