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Machine translation
1. (WO2008097504) USE OF A TRPM5 INHIBITOR TO REGULATE INSULIN AND GLP-1 RELEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/097504    International Application No.:    PCT/US2008/001445
Publication Date: 14.08.2008 International Filing Date: 04.02.2008
IPC:
A61K 31/655 (2006.01), A61K 31/415 (2006.01)
Applicants: REDPOINT BIO CORPORATION [US/US]; 7 Graphics Drive, Ewing, NJ 08628 (US) (For All Designated States Except US).
LEE, S., Paul [US/US]; (US) (For US Only).
ZHOU, Peihong [CN/US]; (US) (For US Only).
BUBER, M.N., Tulu [US/US]; (US) (For US Only).
CERNE, Rok [SI/US]; (US) (For US Only).
BRYANT, Robert [US/US]; (US) (For US Only).
SALEMME, F., Raymond [US/US]; (US) (For US Only).
MORGAN, Gillian [US/US]; (US) (For US Only)
Inventors: LEE, S., Paul; (US).
ZHOU, Peihong; (US).
BUBER, M.N., Tulu; (US).
CERNE, Rok; (US).
BRYANT, Robert; (US).
SALEMME, F., Raymond; (US).
MORGAN, Gillian; (US)
Agent: SHEA, Timothy, J., Jr.; Sterne, Kessler, Goldstein & Fox P.L.L.C., 1100 New York Avenue, N.W., Washington, DC 20005-3934 (US)
Priority Data:
60/887,996 02.02.2007 US
61/016,394 21.12.2007 US
Title (EN) USE OF A TRPM5 INHIBITOR TO REGULATE INSULIN AND GLP-1 RELEASE
(FR) UTILISATION D'UN INHIBITEUR DE TRPM5 POUR RÉGULER UNE SÉCRÉTION D'INSULINE ET DE GLP-1
Abstract: front page image
(EN)The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.
(FR)L'invention concerne des procédés d'amélioration d'une sécrétion d'insuline, d'une sécrétion de GLP-1, et d'une sensibilité à l'insuline, des procédés d'augmentation de l'expression du gène d'insuline, des procédés de diminution de sécrétion et de vidange gastrique, et de diminution de sécrétion de glucagons, des procédés d'inhibition de prise alimentaire, et des procédés de traitement du diabète sucré, du syndrome d'insuline-résistance, de l'hyperglycémie et de l'obésité, comprenant l'administration à un sujet d'une quantité efficace d'un inhibiteur de TRPM5.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)