WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |

Search International and National Patent Collections
World Intellectual Property Organization
Machine translation
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/096841    International Application No.:    PCT/JP2008/052096
Publication Date: 14.08.2008 International Filing Date: 08.02.2008
C07D 207/16 (2006.01), A61K 31/4025 (2006.01), A61P 3/10 (2006.01), A61P 43/00 (2006.01)
Applicants: KYORIN PHARMACEUTICAL CO., LTD. [JP/JP]; 5, Kanda Surugadai 2-chome, Chiyoda-ku Tokyo 1018311 (JP) (For All Designated States Except US).
FUKUDA, Yasumichi [JP/JP]; (JP) (For US Only).
ASAHINA, Yoshikazu [JP/JP]; (JP) (For US Only).
NAGATA, Eri [JP/JP]; (JP) (For US Only).
MURAKAMI, Koji [JP/JP]; (JP) (For US Only).
HASE, Shoko [JP/JP]; (JP) (For US Only)
Inventors: FUKUDA, Yasumichi; (JP).
ASAHINA, Yoshikazu; (JP).
NAGATA, Eri; (JP).
HASE, Shoko; (JP)
Agent: MIZUNO, Katsufumi; 721, Marunouchi-Nakadori Bldg., 2-3, Marunouchi 2-chome, Chiyoda-ku, Tokyo 1000005 (JP)
Priority Data:
2007-030801 09.02.2007 JP
(JA) 二量化シクロ誘導体
Abstract: front page image
(EN)[PROBLEMS] To provide a novel dimerized cyclo derivative having excellent DPP-IV inhibitory activity or a pharmacologically acceptable salt thereof, and a prophylactic and/or therapeutic agent for a DPP-IV-related disease which comprises the derivative or the pharmacologically acceptable salt thereof as an active ingredient. [MEANS FOR SOLVING PROBLEMS] Disclosed is a dimerized cyclo derivative represented by the general formula (1) or a pharmacologically acceptable salt thereof (e.g., 1,2-ethanediol bis[4-[2-[(2S,4S)-2-cyano-4- fluoropyrrolidin-1-yl]acetyl]aminobicyclo[2.2.2]octane-1- carboxylate]).
(FR)L'invention vise à proposer un nouveau dérivé cyclo dimérisé présentant une excellente activité inhibitrice de DPP-IV ou un sel pharmacologiquement acceptable de celui-ci, et un agent prophylactique et/ou thérapeutique pour une maladie apparentée à DPP-IV qui comprend le dérivé ou le sel pharmacologiquement acceptable de celui-ci comme principe actif. À cet effet, l'invention décrit un dérivé cyclo dimérisé représenté par la formule générale (1) ou un sel pharmacologiquement acceptable de celle-ci (par exemple 1,2-éthanediol bis[4-[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]acétyl]aminobicyclo[2.2.2]octane-1-carboxylate]) .
(JA) 【課題】優れたDPP-IV阻害活性を有する新規な二量化シクロ誘導体または薬理学的に許容されるその塩、並びにそれらを有効成分とするDPP-IVが関与する疾患に対する予防および/または治療剤を提供する。  【解決手段】  一般式(1)で表される二量化シクロ誘導体または薬理学的に許容されるその塩(具体例:1,2-エタンジオール ビス[4-[2-[(2S,4S)-2-シアノ-4-フルオロピロリジン-1-イル]アセチル]アミノビシクロ[2.2.2]オクタン-1-カルボキシラート])。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)