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Machine translation
1. (WO2008096811) ATTENUATED MINUS-STRANDED RNA VIRUS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/096811    International Application No.:    PCT/JP2008/052016
Publication Date: 14.08.2008 International Filing Date: 07.02.2008
IPC:
C12N 15/09 (2006.01), C12N 7/00 (2006.01), C07K 14/08 (2006.01), C07K 14/115 (2006.01)
Applicants: DNAVEC CORPORATION [JP/JP]; 1-25-11, Kannondai, Tsukuba-shi, Ibaraki 3050856 (JP) (For All Designated States Except US).
YOSHIZAKI, Mariko [JP/JP]; (JP) (For US Only).
INOUE, Makoto [JP/JP]; (JP) (For US Only).
HASEGAWA, Mamoru [JP/JP]; (JP) (For US Only)
Inventors: YOSHIZAKI, Mariko; (JP).
INOUE, Makoto; (JP).
HASEGAWA, Mamoru; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 1-1-1, Oroshi-machi Tsuchiura-shi Ibaraki 3000847 (JP)
Priority Data:
2007-027520 07.02.2007 JP
Title (EN) ATTENUATED MINUS-STRANDED RNA VIRUS
(FR) VIRUS À ARN À BRIN NÉGATIF ATTÉNUÉ
(JA) 弱毒化マイナス鎖RNAウイルス
Abstract: front page image
(EN)Disclosed is attenuated minus-stranded RNA virus. It is found that the mutation of an amino acid residue at position-1214 in the amino acid sequence for Sendai virus L-protein (Y1214F) can inhibit the genome replication activity and/or the genome transcription activity of the virus. It is also found that a cytotoxicity or immunological response can be reduced compared with the original one by deleting a specific gene from a viral genome.
(FR)L'invention concerne un virus à ARN à brin négatif atténué. Il a été trouvé que la mutation d'un résidu d'acide aminé au niveau de la position 1214 dans la séquence d'acides aminés de la protéine L du virus Sendai (Y1214F) pouvait inhiber l'activité de réplication du génome et/ou l'activité de transcription du génome du virus. Il a également été trouvé que la cytotoxicité ou la réponse immunologique pouvait être réduite par rapport au virus d'origine en supprimant un gène particulier d'un génome viral.
(JA) 本発明は、弱毒化しているマイナス鎖RNAウイルスを提供することを課題とする。本発明者らは、センダイウイルスのL蛋白質のアミノ酸配列における1214番目のアミノ酸の変異(Y1214F)が、ウイルスのゲノム複製活性および/または転写活性を抑制することを見出した。またウイルスゲノムからのある特定の遺伝子を欠失させることで、従来に比べ更に細胞傷害性や免疫反応の軽減を図れることを見出し、本発明を完成させた。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)