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1. (WO2008096722) AGENT FOR PREVENTING BLEEDING FROM CEREBRAL CORTICAL VEIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/096722    International Application No.:    PCT/JP2008/051804
Publication Date: 14.08.2008 International Filing Date: 05.02.2008
IPC:
A61K 33/14 (2006.01), A61J 1/05 (2006.01), A61K 31/19 (2006.01), A61K 31/7004 (2006.01), A61K 33/10 (2006.01), A61P 7/04 (2006.01), A61P 41/00 (2006.01), A61P 43/00 (2006.01)
Applicants: OTSUKA PHARMACEUTICAL FACTORY, INC. [JP/JP]; 115, Aza Kuguhara, Tateiwa, Muya-cho, Naruto-shi, Tokushima 7728601 (JP) (For All Designated States Except US).
FUJITA, Yasutaka [JP/JP]; (JP) (For US Only).
DOI, Kazuhisa [JP/JP]; (JP) (For US Only).
KAMIKAWA, Shuji [JP/JP]; (JP) (For US Only)
Inventors: FUJITA, Yasutaka; (JP).
DOI, Kazuhisa; (JP).
KAMIKAWA, Shuji; (JP)
Agent: SAEGUSA, Eiji; Kitahama TNK Building 1-7-1, Doshomachi Chuo-ku, Osaka-shi Osaka 5410045 (JP)
Priority Data:
2007-028975 08.02.2007 JP
Title (EN) AGENT FOR PREVENTING BLEEDING FROM CEREBRAL CORTICAL VEIN
(FR) AGENT POUR EMPÊCHER UNE HÉMORRAGIE DE LA VEINE CORTICALE CÉRÉBRALE
(JA) 脳表血管出血抑制剤
Abstract: front page image
(EN)Disclosed is an agent for preventing the bleeding from a cerebral cortical vein, which comprises an aqueous solution containing 120 to 160 mEq/L of a sodium ion, 1 to 5 mEq/L of a calcium ion and 75 to 165 mEq/L of a chlorine ion. The agent may further contain 1 to 5 mEq/L of a potassium ion. Also disclosed is a packaged product of a container accommodating the agent therein. The agent can prevent or reduce the bleeding from a cerebral cortical vein effectively in the field of neurosurgery including intracranial surgery, thereby providing a sufficiently spacious operation field during a surgery or preventing the occurrence of any disorder after a surgery.
(FR)L'invention porte sur un agent pour empêcher l'hémorragie d'une veine corticale cérébrale. Cet agent comprend une solution aqueuse contenant 120 à 160 mEq/l d'ions sodium, 1 à 5 mEq/l d'ions calcium et 75 à 165 mEq/l d'ions chlore. L'agent peut en outre contenir 1 à 5 mEq/l d'ions potassium. L'invention concerne également un produit conditionné d'un conteneur recevant l'agent dans celui-ci. L'agent permet d'empêcher ou de réduire l'hémorragie à partir d'une veine corticale cérébrale de manière efficace dans le domaine de la neurochirurgie comprenant la chirurgie intracrânienne, fournissant ainsi un champ opératoire suffisamment spacieux pendant une chirurgie ou empêchant l'apparition de tout trouble après une chirurgie.
(JA) 本発明は、ナトリウムイオン120~160 mEq/L、カルシウムイオン1~5 mEq/L、及び塩素イオン75~165mEq/Lを含有する水溶液からなる脳表血管出血抑制剤;更に、カリウムイオンを1~5 mEq/L含有する脳表血管出血抑制剤;並びにこれらの脳表血管出血抑制剤を収容した容器の包装体を提供するものである。  本発明の脳表血管出血抑制剤によれば、頭蓋内手術などの脳神経外科領域において、脳表血管からの出血を効果的に防止乃至抑制して、手術時の視野の確保や術後の障害の発生を抑制できる。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)