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Machine translation
1. (WO2008096260) 3-AMINO-PYRROLO[3,4-C] PYRAZOLE- 5 (1H, 4H, 6H) CARBALDEHYDE DERIVATIVES AS PKC INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/096260    International Application No.:    PCT/IB2008/000297
Publication Date: 14.08.2008 International Filing Date: 04.02.2008
IPC:
C07D 487/04 (2006.01), A61K 31/4162 (2006.01), A61P 3/00 (2006.01)
Applicants: PFIZER INC. [US/US]; 235 East 42nd, New York, New York 10017 (US) (For All Designated States Except US).
LI, Hui [CN/US]; (US) (For US Only).
NUKUI, Seiji [JP/US]; (US) (For US Only).
SCALES, Stephanie Anne [US/US]; (US) (For US Only).
TENG, Min [US/US]; (US) (For US Only).
YIN, Chunfeng [CN/US]; (US) (For US Only)
Inventors: LI, Hui; (US).
NUKUI, Seiji; (US).
SCALES, Stephanie Anne; (US).
TENG, Min; (US).
YIN, Chunfeng; (US)
Agent: FULLER, Grover F. Jr.; Pfizer Inc., 150 East 42nd Street, New York, New York 10017 (US)
Priority Data:
60/888,749 07.02.2007 US
60/989,086 19.11.2007 US
61/020,965 14.01.2008 US
Title (EN) 3-AMINO-PYRROLO[3,4-C] PYRAZOLE- 5 (1H, 4H, 6H) CARBALDEHYDE DERIVATIVES AS PKC INHIBITORS
(FR) NOUVEAUX DÉRIVÉS DE 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1<I>H,</I>4<I>H</I>,6<I>H</I>) CARBALDÉHYDE
Abstract: front page image
(EN)The present invention relates to compounds and pharmaceutically acceptable salts of Formulas A and B: (A) and (B) wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined above. The invention further relates to pharmaceutical compositions comprising the compounds and pharmaceutically acceptable salts and to methods of treating diabetes mellitus and its complications, cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease and dermatological disase pression, virus diseases, inflammatory disorders, or diseases in which the liver is a target organ.
(FR)La présente invention porte sur des composés et des sels pharmaceutiquement acceptables des Formules A et B : (A) et (B) dans lesquelles A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9 et R10 sont tels que définis ci-dessus. L'invention porte en outre sur des compositions pharmaceutiques comprenant les composés et sels pharmaceutiquement acceptables et sur des procédés pour traiter le diabète sucré et ses complications, le cancer, l'ischémie, l'inflammation, les troubles du système nerveux central, la maladie cardiovasculaire, la maladie d'Alzheimer et les ulcères cutanés dus à la pression, les maladies virales, les troubles inflammatoires ou les maladies dans lesquelles le foie est un organe cible.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)