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1. WO2008096129 - NITROGEN CONTAINING HETROCYCLIC COMPOUNDS USEFUL AS BIFUNCTIONAL MODULATORS OF M3 RECEPTORS AND BETA- 2 RECEPTORS

Publication Number WO/2008/096129
Publication Date 14.08.2008
International Application No. PCT/GB2008/000407
International Filing Date 06.02.2008
IPC
C07D 413/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 417/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 417/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
A61K 31/41 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A61P 1/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
A61P 15/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
10for impotence
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
Applicants
  • ARGENTA DISCOVERY LTD [GB]/[GB] (AllExceptUS)
  • ASTRAZENECA AB [SE]/[SE] (AllExceptUS)
  • EDWARDS, Christine [GB]/[GB] (UsOnly)
  • KINDON, Nicholas [GB]/[GB] (UsOnly)
  • RAY, Nicholas, Charles [GB]/[GB] (UsOnly)
  • SUTTON, Jonathan, Mark [GB]/[GB] (UsOnly)
  • ALCARAZ, Lilian [FR]/[GB] (UsOnly)
Inventors
  • EDWARDS, Christine
  • KINDON, Nicholas
  • RAY, Nicholas, Charles
  • SUTTON, Jonathan, Mark
  • ALCARAZ, Lilian
Agents
  • MERCER, Christopher, Paul
Priority Data
0702381.507.02.2007GB
0702415.107.02.2007GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NITROGEN CONTAINING HETROCYCLIC COMPOUNDS USEFUL AS BIFUNCTIONAL MODULATORS OF M3 RECEPTORS AND BETA- 2 RECEPTORS
(FR) COMPOSÉS HÉTROCYCLIQUES CONTENANT DE L'AZOTE UTILES COMME MODULATEURS BIFONCTIONNELS DE RÉCEPTEURS M3 ET DE RÉCEPTEURS BÉTÂ-2
Abstract
(EN)
The present invention relates to a compound of formula (I) having both M3 receptor antagonist and β2 agonist activity; a composition comprising such a compound; the use of such a compound in therapy (such as asthma or COPD); and a method of treating a patient with such a compound; wherein R1, R3, R4, R5, R6, La, Z1, W, V, A and X are as defined herein.
(FR)
La présente invention porte sur un composé de formule (I) présentant une activité à la fois antagoniste du récepteur M3 et agoniste β2 ; sur une composition incluant un tel composé ; sur l'utilisation d'un tel composé en thérapie (telle que l'asthme ou le COPD) ; sur un procédé de traitement d'un patient par un tel composé, dans lequel R1, R3, R4, R5, R6, La, Z1, W, V, A et X sont tels que définis présentement.
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