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1. (WO2008096129) NITROGEN CONTAINING HETROCYCLIC COMPOUNDS USEFUL AS BIFUNCTIONAL MODULATORS OF M3 RECEPTORS AND BETA- 2 RECEPTORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/096129    International Application No.:    PCT/GB2008/000407
Publication Date: 14.08.2008 International Filing Date: 06.02.2008
IPC:
C07D 413/12 (2006.01), C07D 417/12 (2006.01), C07D 417/14 (2006.01), A61K 31/41 (2006.01), A61P 1/00 (2006.01), A61P 9/00 (2006.01), A61P 11/00 (2006.01), A61P 13/00 (2006.01), A61P 15/10 (2006.01), A61P 17/00 (2006.01), A61P 19/00 (2006.01), A61P 25/00 (2006.01), A61P 27/02 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01)
Applicants: ARGENTA DISCOVERY LTD [GB/GB]; 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR (GB) (For All Designated States Except US).
ASTRAZENECA AB [SE/SE]; S-151 85 Soderjalje (SE) (For All Designated States Except US).
EDWARDS, Christine [GB/GB]; (GB) (For US Only).
KINDON, Nicholas [GB/GB]; (GB) (For US Only).
RAY, Nicholas, Charles [GB/GB]; (GB) (For US Only).
SUTTON, Jonathan, Mark [GB/GB]; (GB) (For US Only).
ALCARAZ, Lilian [FR/GB]; (GB) (For US Only)
Inventors: EDWARDS, Christine; (GB).
KINDON, Nicholas; (GB).
RAY, Nicholas, Charles; (GB).
SUTTON, Jonathan, Mark; (GB).
ALCARAZ, Lilian; (GB)
Agent: MERCER, Christopher, Paul; Carpmaels & Ransford, 43-45 Bloomsbury Square, London WC1A 2RA (GB)
Priority Data:
0702381.5 07.02.2007 GB
0702415.1 07.02.2007 GB
Title (EN) NITROGEN CONTAINING HETROCYCLIC COMPOUNDS USEFUL AS BIFUNCTIONAL MODULATORS OF M3 RECEPTORS AND BETA- 2 RECEPTORS
(FR) COMPOSÉS HÉTROCYCLIQUES CONTENANT DE L'AZOTE UTILES COMME MODULATEURS BIFONCTIONNELS DE RÉCEPTEURS M3 ET DE RÉCEPTEURS BÉTÂ-2
Abstract: front page image
(EN)The present invention relates to a compound of formula (I) having both M3 receptor antagonist and β2 agonist activity; a composition comprising such a compound; the use of such a compound in therapy (such as asthma or COPD); and a method of treating a patient with such a compound; wherein R1, R3, R4, R5, R6, La, Z1, W, V, A and X are as defined herein.
(FR)La présente invention porte sur un composé de formule (I) présentant une activité à la fois antagoniste du récepteur M3 et agoniste β2 ; sur une composition incluant un tel composé ; sur l'utilisation d'un tel composé en thérapie (telle que l'asthme ou le COPD) ; sur un procédé de traitement d'un patient par un tel composé, dans lequel R1, R3, R4, R5, R6, La, Z1, W, V, A et X sont tels que définis présentement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)