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Machine translation
1. (WO2008095944) 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/095944    International Application No.:    PCT/EP2008/051428
Publication Date: 14.08.2008 International Filing Date: 05.02.2008
IPC:
C07D 471/04 (2006.01), A61K 31/437 (2006.01), A61P 19/02 (2006.01)
Applicants: EISAI R&D MANAGEMENT CO. LTD. [JP/JP]; 6-10 Koishikawa, 4-Chome, Bunkyo-Ku, Tokyo 112-8088 (JP) (For All Designated States Except US).
GRACZYK, Piotr Pawel [PL/GB]; (GB) (For US Only).
DIMOPOULOS, Paschalis [GR/GB]; (GB) (For US Only).
KHAN, Afzal [GB/GB]; (GB) (For US Only).
BHATIA, Gurpreet Singh [GB/GB]; (GB) (For US Only).
FARTHING, Christopher Neil [GB/GB]; (GB) (For US Only)
Inventors: GRACZYK, Piotr Pawel; (GB).
DIMOPOULOS, Paschalis; (GB).
KHAN, Afzal; (GB).
BHATIA, Gurpreet Singh; (GB).
FARTHING, Christopher Neil; (GB)
Agent: CROOKS, Elizabeth Caroline; Kilburn & Strode, 20 Red Lion Street, London WC1R 4PJ (GB)
Priority Data:
0702265.0 06.02.2007 GB
Title (EN) 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE
(FR) DÉRIVÉS DE 7-AZAINDOLE ET LEUR UTILISATION DANS L'INHIBITION DE C-JUN N-TERMINAL KINASE
Abstract: front page image
(EN)The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof, the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and the use in medicine and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of said compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them.
(FR)La présente invention porte sur un composé de formule (I) ou un sel pharmaceutiquement acceptable de celui-ci ; sur l'utilisation de composé de formule (I) ou d'un sel pharmaceutiquement acceptable de celui-ci dans l'inhibition de l'activité C-Jun N-terminal kinase (JNK) ; et sur l'utilisation en médecine et, en particulier, dans le traitement de troubles neurodégénératifs, de maladies inflammatoires et/ou de maladies auto-immunes. L'invention porte également sur des procédés de fabrication desdits composés de formule (I) ou sur un sel pharmaceutiquement acceptable de ceux-ci, et sur des compositions les contenant.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)