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1. (WO2008094713) DETECTION AND TREATMENT OF NEURODEGENERATIVE TAUOPATHIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/094713    International Application No.:    PCT/US2008/001479
Publication Date: 07.08.2008 International Filing Date: 31.01.2008
IPC:
G01N 33/53 (2006.01), G01N 33/567 (2006.01), G01N 33/542 (2006.01), G01N 33/537 (2006.01), G01N 33/566 (2006.01), A01K 67/00 (2006.01), A01K 67/033 (2006.01)
Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street, Suite 200, Philadelphia, PA 19104-6283 (US) (For All Designated States Except US).
TROJANOWSKI, John, Q. [US/US]; (US) (For US Only).
LEE, Virginia, M.y. [US/US]; (US) (For US Only)
Inventors: TROJANOWSKI, John, Q.; (US).
LEE, Virginia, M.y.; (US)
Agent: CALDWELL, John, W.; Woodcock Washburn Llp, Cira Centre, 12th Floor, 2929 Arch Street, Philadelphia, PA 19104-2891 (US)
Priority Data:
60/887,554 31.01.2007 US
Title (EN) DETECTION AND TREATMENT OF NEURODEGENERATIVE TAUOPATHIES
(FR) DÉTECTION ET TRAITEMENT DE TAUOPATHIES NEURODÉGÉNÉRATIVES
Abstract: front page image
(EN)Provided are methods of assessing the absence or presence of a tauopathy in a subject comprising characterizing the microglial activation state in a neurological tissue of the subject prior to the clinical manifestation of said tauopathy. Also provided are methods of assessing the absence of presence of a tauopathy in a subject comprising determining the absence or presence of synaptic pathology in a neurological tissue of the subject prior to the clinical manifestation of said tauopathy. Also disclosed are transgenic PS19 mice expressing human P301S mutant tau, and methods for identifying an agent that modulates the onset or progression of a neurodegenerative tauopathy.
(FR)L'invention concerne des procédés d'évaluation de l'absence ou de la présence d'une tauopathie chez un sujet comprenant la caractérisation de l'état d'activation microgliale dans un tissu neurologique du sujet avant la manifestation clinique de ladite tauopathie. Sont également prévus des procédés d'évaluation de l'absence ou de la présence d'une tauopathie chez un sujet comprenant la détermination de l'absence ou de la présence de pathologie synaptique dans un tissu neurologique du sujet avant la manifestation clinique de ladite tauopathie. Sont également décrites des souris PS19 transgéniques exprimant un tau mutant P301S humain, et des procédés pour identifier un agent qui module le début ou la progression d'une tauopathie neurodégénérative.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)