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1. (WO2008094583) METHODS AND DEVICES FOR MRI-BASED MEASUREMENT OF AXONAL TRANSPORT IN VIVO AND DELIVERY OF THERAPEUTIC SUBSTANCES TO THE CNS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/094583    International Application No.:    PCT/US2008/001205
Publication Date: 07.08.2008 International Filing Date: 30.01.2008
IPC:
A61B 5/055 (2006.01)
Applicants: THE GENERAL HOSPITAL CORPORATION [US/US]; 55 Fruit Street, Boston, MA 02114 (US) (For All Designated States Except US).
MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue, Cambridge, MA 02139 (US) (For All Designated States Except US).
BROWN, Robert [US/US]; (US) (For US Only).
TOWNSEND, Seth [US/US]; (US) (For US Only).
LANGER, Robert [US/US]; (US) (For US Only).
FRANCIS, Jonathan, W. [US/US]; (US) (For US Only).
EVRONY, Gilad [US/IL]; (IL) (For US Only)
Inventors: BROWN, Robert; (US).
TOWNSEND, Seth; (US).
LANGER, Robert; (US).
FRANCIS, Jonathan, W.; (US).
EVRONY, Gilad; (IL)
Agent: VAN AMSTERDAM, John, R.; Wolf, Greenfield & Sacks, P.C., Federal Reserve Plaza, 600 Atlantic Avenue, Boston, MA 02210-2206 (US)
Priority Data:
60/898,234 30.01.2007 US
Title (EN) METHODS AND DEVICES FOR MRI-BASED MEASUREMENT OF AXONAL TRANSPORT IN VIVO AND DELIVERY OF THERAPEUTIC SUBSTANCES TO THE CNS
(FR) PROCÉDÉS ET DISPOSITIFS PERMETTANT DE MESURER PAR IRM LE TRANSPORT AXONAL IN VIVO ET L'ADMINISTRATION DE SUBSTANCES THÉRAPEUTIQUES AU SYSTÈME NERVEUX CENTRAL
Abstract: front page image
(EN)Aspects of the invention relate to tetanus toxin C fragment conjugated to a MRI contrast agent, iron nanoparticle, or biodegradable nanoparticle. Aspects of the invention relate to methods of determining neurodegeneration in a subject by administering a tetanus toxin C fragment conjugated to a MRI contrast agent, iron nanoparticle, or biodegradable nanoparticle and measuring axonal transport.
(FR)La présente invention concerne, selon certains de ses aspects, un fragment C de toxine du tétanos conjugué à un agent de contraste d'IRM, une nanoparticule de fer ou une nanoparticule biodégradable. Certains aspects de l'invention portent sur des procédés permettant de déterminer la neurodégénérescence chez un sujet grâce à l'administration d'un fragment C de toxine du tétanos conjugué à un agent de contraste d'IRM, une nanoparticule de fer ou une nanoparticule biodégradable et à la mesure du transport axonal.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)