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1. (WO2008094275) PEPTIDES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH NITRIC OXIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/094275    International Application No.:    PCT/US2007/068175
Publication Date: 07.08.2008 International Filing Date: 03.05.2007
IPC:
A61K 38/00 (2006.01), A61K 38/12 (2006.01)
Applicants: NEW YORK UNIVERSITY [US/US]; 70 Washington Square South, New York, NY 10012 (US) (For All Designated States Except US).
NUDLER, Evgeny, A. [US/US]; (US) (For US Only).
RAFIKOV, Ruslan, R. [RU/US]; (US) (For US Only)
Inventors: NUDLER, Evgeny, A.; (US).
RAFIKOV, Ruslan, R.; (US)
Agent: LUDWIG, S. Peter; Darby & Darby P.C., P.O. Box 770, Church Street Station, New York, NY 10008-0770 (US)
Priority Data:
60/887,314 30.01.2007 US
Title (EN) PEPTIDES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH NITRIC OXIDE
(FR) PEPTIDES DESTINÉS À ÊTRE UTILISÉS DANS UN TRAITEMENT D'ÉTATS ASSOCIÉS À DE L'OXYDE NITRIQUE
Abstract: front page image
(EN)Isolated short peptides comprising the amino acid sequence Cys-Glu-Phe-His (CEFH) and analogs thereof The CEFH peptides are effective in mediating the denitration of 3-nιtrotyrosιnes (3-NT) in cellular proteins thereby preventing tissue damage associated with excess nitric oxide (NO) and its reactive species, and useful in the treatment of ischemia/reperfusion (I/R) injury of various tissues and other disorders related to nitric oxide toxicity.
(FR)L'invention concerne des peptides courts isolés comprenant la séquence d'acides aminés Cys-Glu-Phe-His (CEFH), et leurs analogues. Les peptides CEFH sont efficaces pour modérer la dénitration de 3-nitrotyrosines (3-NT) dans des protéines cellulaires, empêchant ainsi des dommages tissulaires associés à un excédent d'oxyde nitrique (NO) et ses espèces réactives ainsi que pour traiter des dommages d'une ischémie/reperfusion (I/R) de divers tissus et autres troubles liés à une toxicité d'oxyde nitrique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)