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1. (WO2008093886) MCF7-DERIVED CELL
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/093886    International Application No.:    PCT/JP2008/051979
Publication Date: 07.08.2008 International Filing Date: 30.01.2008
Chapter 2 Demand Filed:    01.12.2008    
IPC:
C12N 5/06 (2006.01), A01K 67/027 (2006.01), C12Q 1/02 (2006.01), G01N 33/15 (2006.01), G01N 33/50 (2006.01)
Applicants: Bio Matrix Research, Inc. [JP/JP]; 105 Higashifukai, Nagareyama-shi, Chiba 2700101 (JP) (For All Designated States Except US).
Tokyo University of Science [JP/JP]; 3, Kagurazaka 1-chome, Shinjuku-ku, Tokyo 1628601 (JP) (For All Designated States Except US).
IMADA, Mika [JP/JP]; (JP) (For US Only).
KOJIMA, Hiroko [JP/JP]; (JP) (For US Only).
UCHINO, Masahiro [JP/JP]; (JP) (For US Only).
UTSUGI, Takahiko [JP/JP]; (JP) (For US Only).
MURAKAMI, Yasufumi [JP/JP]; (JP) (For US Only)
Inventors: IMADA, Mika; (JP).
KOJIMA, Hiroko; (JP).
UCHINO, Masahiro; (JP).
UTSUGI, Takahiko; (JP).
MURAKAMI, Yasufumi; (JP)
Agent: INABA, Yoshiyuki; TMI ASSOCIATES, 23rd Floor, Roppongi Hills Mori Tower, 6-10-1 Roppongi, Minato-ku, Tokyo 1066123 (JP)
Priority Data:
2007-020101 30.01.2007 JP
Title (EN) MCF7-DERIVED CELL
(FR) CELLULE DÉRIVÉE DE MCF7
(JA) MCF7由来細胞
Abstract: front page image
(EN)The object is to produce a model which acquires a high metastatic capability and a high invasive capability of a cell related to breast cancer. Specifically disclosed is a MCF7-derived cell which is derived from a MCF7 cell and has a significantly higher invasive capability or metastatic capability compared to a MCF7 cell. The MCF7-derived cell can be produced by collecting a MCF7 cell that acquires a capability of passing through a basement membrane preparation such as Matrigel or an analogue thereof.
(FR)L'invention a pour but de produire un modèle qui acquiert une haute capacité métastatique et une haute capacité invasive d'une cellule liée au cancer du sein. Plus spécifiquement, l'invention concerne une cellule dérivée de MCF7, qui est dérivée d'une cellule MCF7 et présente une capacité invasive ou une capacité métastatique significativement plus élevée, comparativement à une cellule MCF7. La cellule dérivée de MCF7 peut être produite par collecte d'une cellule MCF7 qui acquiert une capacité de traverser une préparation de membrane basale, telle que Matrigel ou analogue.
(JA)本発明は、乳癌関連細胞の高転移能・高浸潤能獲得モデルを作製することを目的とする。本発明は、MCF7細胞に由来する細胞であって、MCF7細胞に比較して有意に高い浸潤能または転移能を有するMCF7由来細胞を提供する。本発明のMCF7由来細胞は、マトリゲル等の基底膜調製物又はその類似物通過能を獲得したMCF7細胞を回収することによって得ることができる。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)