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1. (WO2008093853) SOLID OF MACROLIDE COMPOUND, METHOD FOR PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/093853    International Application No.:    PCT/JP2008/051695
Publication Date: 07.08.2008 International Filing Date: 28.01.2008
IPC:
C07D 407/06 (2006.01), A61K 31/496 (2006.01), A61P 35/00 (2006.01)
Applicants: EISAI R & D MANAGEMENT CO., LTD. [JP/JP]; 6-10, Koishikawa 4-chome, Bunkyo-ku, Tokyo 1128088 (JP) (For All Designated States Except US).
MERCIAN CORPORATION [JP/JP]; 5-8, Kyobashi 1-chome, Chuo-ku, Tokyo 1048305 (JP) (For All Designated States Except US).
ISHIHARA, Hiroshi [JP/JP]; (JP) (For US Only).
SASHO, Manabu [JP/JP]; (JP) (For US Only).
SATO, Keizo [JP/JP]; (JP) (For US Only).
KAMAHARA, Takashi [JP/JP]; (JP) (For US Only).
YOSHIDA, Masashi [JP/JP]; (JP) (For US Only)
Inventors: ISHIHARA, Hiroshi; (JP).
SASHO, Manabu; (JP).
SATO, Keizo; (JP).
KAMAHARA, Takashi; (JP).
YOSHIDA, Masashi; (JP)
Agent: FURUYA, Satoshi; Hamacho-Hanacho Building 6th Floor, 2-17-8, Nihonbashi-Hamacho, Chuo-ku, Tokyo 1030007 (JP)
Priority Data:
2007-017491 29.01.2007 JP
60/888,257 05.02.2007 US
Title (EN) SOLID OF MACROLIDE COMPOUND, METHOD FOR PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
(FR) SOLIDE DE COMPOSÉ DE MACROLIDE, SON PROCÉDÉ DE FABRICATION ET COMPOSITION PHARMACEUTIQUE LE COMPRENANT
(JA) マクロライド系化合物の固体およびその製造法並びにその医薬組成物
Abstract: front page image
(EN)Disclosed are: a solid of a compound represented by the formula (I), which is homogeneous and highly pure to such an extent that it can be used as an original drug for the preparation of a pharmaceutical product and has good workability; a method for producing the solid; and a pharmaceutical composition comprising the solid. A solid of (8E,12E,14E)-7-[(4- cycloheptylpiperazin-1-yl)-carbonyl]oxy-3,6,16,21- tetrahydroxy-6,10,12,16,20-pentamethyl-18,19-epoxytricosa- 8,12,14-trien-11-olide is found, which has a homogenized specification and good workability.
(FR)L'invention porte sur un solide d'un composé représenté par la formule (I), qui est homogène et hautement pur dans une mesure telle qu'il peut être utilisé comme médicament original pour la préparation d'un produit pharmaceutique et présente une bonne aptitude à la mise en œuvre ; sur un procédé de fabrication du solide ; et sur une composition pharmaceutique comprenant le solide. Un solide de (8E,12E,14E)-7-[(4-cycloheptylpipérazin-1-yl)-carbonyl]oxy-3,6,16,21- tétrahydroxy-6,10,12,16,20-pentaméthyl-18,19-époxytricosa- 8,12,14-trièn-11-olide a été trouvé, lequel présente une formulation homogénéisée et une bonne aptitude à la mise en œuvre.
(JA)本発明は、医薬品製造用の原薬として均質で高い純度を有し、かつ作業性が良好である式(I)の化合物の固体及びその製造法並びにその医薬組成物を提供する。均一化された規格を有し、作業性が良好な(8E,12E,14E)−7−{(4−シクロヘプチルピペラジン−1−イル)カルボニル}オキシ−3,6,16,21−テトラヒドロキシ−6,10,12,16,20−ペンタメチル−18,19−エポキシトリコサ−8,12,14−トリエン−11−オリドの固体を見出した。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)