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1. (WO2008093165) THE USE OF PGIL OHGOSACCHARYLTRANSFERASE FOR O-GLYCOSYLATING PROTEINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/093165    International Application No.:    PCT/IB2007/004486
Publication Date: 07.08.2008 International Filing Date: 13.12.2007
IPC:
C12P 21/02 (2006.01), A61K 38/16 (2006.01), A61K 39/02 (2006.01), A61K 39/095 (2006.01), A61P 31/04 (2006.01), A61P 37/04 (2006.01), C12N 15/00 (2006.01), C07K 9/00 (2006.01), C12N 15/63 (2006.01)
Applicants: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA [CA/CA]; Suite 4000, 8308-1114 Street Edmonton, Alberta T6G 2E1 (CA) (For All Designated States Except US).
FELDMAN, Mario [AR/CA]; (CA) (For US Only).
FARIDMOAYER, Amirreza [IR/CA]; (CA) (For US Only)
Inventors: FELDMAN, Mario; (CA).
FARIDMOAYER, Amirreza; (CA)
Agent: WHITE, Bradley, J.; Osler, Hoskin & Harcourt LLP 340 Albert Street, Suite 1900 Ottawa, Ontario K1R 7Y6 (CA)
Priority Data:
60/872,403 13.12.2006 US
Title (EN) THE USE OF PGIL OHGOSACCHARYLTRANSFERASE FOR O-GLYCOSYLATING PROTEINS
(FR) PROCÉDÉS ET SYSTÈMES POUR LA O-GLYCOSYLATION DE PROTÉINES
Abstract: front page image
(EN)Described herein are methods and systems for O-glycosylating proteins in vivo or in vitro in any prokaryotic organism. In these methods and systems, DNA comprising a gene that produces a PglL-like oligosaccharyltransferase and DNA comprising a gene that produces a protein to be O-glycosylated are used. The PglL-like oligosaccharyltransferase facilitates the covalent attachment of the glycan to the protein to produce the O-glycosylated protein. The methods and systems described herein provide an approach for the design and production of new vaccines and therapeutic agents for the treatment of various diseases.
(FR)L'invention porte sur des procédés et des systèmes pour la O-glycosylation de protéines in vivo ou in vitro dans n'importe quel organisme procaryote. Dans ces procédés et systèmes, l'ADN comportant un gène qui produit une oligosaccharyltransférase analogue à Pg1L et l'ADN comportant un gène qui produit une protéine devant être O-glycosylée sont utilisés. L'oligosaccharyltransférase analogue à Pg1L facilite la liaison covalente du glycane à la protéine pour donner la protéine O-glycosylée. Les procédés et systèmes décrits fournissent une approche pour la conception et la production de nouveaux vaccins et agents thérapeutiques pour le traitement de diverses maladies.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)