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1. (WO2008092894) MODULATORS OF SCLEROSTIN BINDING PARTNERS FOR TREATING BONE-RELATED DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/092894    International Application No.:    PCT/EP2008/051128
Publication Date: 07.08.2008 International Filing Date: 30.01.2008
IPC:
A61K 38/18 (2006.01), A61P 19/10 (2006.01), A61K 39/395 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35, CH-4056 Basel (CH) (For All Designated States Except US).
LU, Chris Xiangyang [US/US]; (US) (For US Only).
HU, Shou-Ih [US/US]; (US) (For US Only).
KNEISSEL, Michaela [AT/CH]; (CH) (For US Only).
HALLEUX, Christine [BE/CH]; (CH) (For US Only)
Inventors: LU, Chris Xiangyang; (US).
HU, Shou-Ih; (US).
KNEISSEL, Michaela; (CH).
HALLEUX, Christine; (CH)
Agent: VOEGELI-LANGE, Regina; Novartis Pharma Ag, Patent Department, CH-4002 Basel (CH)
Priority Data:
60/887,956 02.02.2007 US
Title (EN) MODULATORS OF SCLEROSTIN BINDING PARTNERS FOR TREATING BONE-RELATED DISORDERS
(FR) MODULATEURS DE PARTENAIRES DE LIAISON DE LA SCLÉROSTINE POUR TRAITER DES TROUBLES LIÉS AUX OS
Abstract: front page image
(EN)The present invention relates to the use of modulators of the sclerostin: sclerostin- binding-partner interaction for the treatment, amelioration, and diagnosis of sclerostin-related disorders, e.g., osteoporosis and sclerosteosis, and sclerostin-related disorders, e.g., cancers and cardiovascular disorders. The invention also relates to the use of sclerostin-binding-partner mimetics for the treatment, amelioration, and diagnosis of sclerostin-related disorders. Assays for the identification of modulators of the sclerostin: sclerostin-binding-partner interaction, as well as the resulting signaling, are also provided.
(FR)La présente invention porte sur l'utilisation de modulateurs de l'interaction sclérostine : partenaire de liaison de la sclérostine pour le traitement, l'amélioration et le diagnostic de troubles liés à la sclérostine, par exemple l'ostéoporose et la sclérostéose, et de troubles liés à la sclérostine, par exemple les cancers et les troubles cardio-vasculaires. L'invention porte également sur l'utilisation de mimétiques de partenaires de liaison de la sclérostine pour le traitement, l'amélioration et le diagnostic de troubles liés à la sclérostine. L'invention porte également sur des analyses pour l'identification de modulateurs de l'interaction sclérostine : partenaire de liaison de la sclérostine, ainsi que sur la signalisation résultante.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)