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1. (WO2008092891) 1-OXA-3-AZASPIRO(4.5)DECAN-2-ONE DERIVATIVES FOR THE TREATMENT OF EATING DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/092891    International Application No.:    PCT/EP2008/051116
Publication Date: 07.08.2008 International Filing Date: 30.01.2008
IPC:
C07D 413/12 (2006.01), C07D 413/14 (2006.01), C07D 417/14 (2006.01), A61K 31/423 (2006.01), A61P 3/00 (2006.01), A61P 25/00 (2006.01)
Applicants: GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House, Berkeley Avenue, Greenford Middlesex UB6 0NN (GB) (For All Designated States Except US).
BENTLEY, Jonathan [GB/IT]; (IT) (For US Only).
BIAGETTI, Matteo [IT/IT]; (IT) (For US Only).
GENSKI, Thorsten [DE/IT]; (IT) (For US Only).
KOPF, Silvia Rosalia [AR/IT]; (IT) (For US Only).
LESLIE, Colin Philip [GB/IT]; (IT) (For US Only).
MELOTTO, Sergio [IT/IT]; (IT) (For US Only)
Inventors: BENTLEY, Jonathan; (IT).
BIAGETTI, Matteo; (IT).
GENSKI, Thorsten; (IT).
KOPF, Silvia Rosalia; (IT).
LESLIE, Colin Philip; (IT).
MELOTTO, Sergio; (IT)
Agent: MAURO, Marina; GlaxoSmithKline, Corporate Intellectual Property CN925.1, 980 Great West Road, Brentford Middlesex TW8 9GS (GB)
Priority Data:
0701962.3 01.02.2007 GB
0720880.4 24.10.2007 GB
0800267.7 08.01.2008 GB
Title (EN) 1-OXA-3-AZASPIRO(4.5)DECAN-2-ONE DERIVATIVES FOR THE TREATMENT OF EATING DISORDERS
(FR) DÉRIVÉS DE 1-OXA-3-AZASPIRO [4,5] DÉCANE-2-ONE POUR LE TRAITEMENT DE TROUBLES DE L'ALIMENTATION
Abstract: front page image
(EN)The present invention relates to novel compounds or a pharmaceutically acceptable salt or solvate thereof, selected from a group consisting of: (trans)-8-({[1-(2-fluorophenyl)-1H-pyrazol-3-yl]amino}methyl)3-(2-fluoro-3-pyridinyl)-1-oxa-3-azaspiro[4.5]decan-2-one; (trans)-8-({[1-(2-fluorophenyl)-1H-pyrazol-3-yl]amino}methyl)-3-(3-pyridazinyl)-1-oxa-3- azaspiro[4.5]decan-2-one; (trans)-8-({[1-(2-fluorophenyl)-1H-pyrazol-3-yl]amino}methyl)-3-(1-methyl-1H-pyrazol-3-yl)- 1-oxa-3-azaspiro[4.5]decan-2-one; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as NPY Y5 receptor antagonists and as agents for the treatment and/or prophylaxis of eating disorders such as a binge eating disorder.
(FR)L'invention concerne de nouveaux composés ou un sel ou solvate pharmaceutiquement acceptable de ceux-ci, choisis dans le groupe composé de (trans)-8-({[1-(2-fluorophényle)-1H-pyrazolo-3-yle]amino}méthyle)-3-(2-fluoro-3-pyridinyle)-1-oxa-3-azaspiro [4,5] décane-2-one; (trans)-8-({[1-(2-fluorophényle)-1H-pyrazolo-3-yle]amino}méthyle)-3-(3-pyridazinyle)-1-oxa-3-azaspiro [4,5] décane-2-one; (trans)-8-({[1-(2-fluorophényle)-1H-pyrazolo-3-yle]amino}méthyle)-3-(1-méthyle-1H-pyrazolo-3-yle)-1-oxa-3-azaspiro [4,5] décane-2-one. L'invention concerne également des procédés de fabrication de ces composés, des compositions pharmaceutiques contenant ces composés et leur utilisation en thérapie, en tant qu'antagonistes du récepteur de NPY Y5, et en tant qu'agents pour le traitement et/ou la prophylaxie de troubles de l'alimentation tels que la frénésie alimentaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)