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1. (WO2008092878) GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/092878    International Application No.:    PCT/EP2008/051084
Publication Date: 07.08.2008 International Filing Date: 30.01.2008
IPC:
C07D 235/02 (2006.01), A61K 31/4166 (2006.01), A61P 25/00 (2006.01), A61P 25/18 (2006.01), A61P 25/28 (2006.01)
Applicants: GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House, Berkeley Avenue, Greenford Middlesex UB6 0NN (GB) (For All Designated States Except US).
UNIVERSITY OF NOTTINGHAM [GB/GB]; University Park, Nottingham NG7 2RD (GB) (For All Designated States Except US).
AHMAD, Nadia, Mamoona [GB/GB]; (GB) (For US Only).
BRANCH, Clive, Leslie [GB/GB]; (GB) (For US Only).
JAXA-CHAMIEC, Albert, Andrzej [GB/GB]; (GB) (For US Only).
LAI, Justine, Yeun Quai [SG/GB]; (GB) (For US Only).
NASH, David, John [GB/GB]; (GB) (For US Only)
Inventors: AHMAD, Nadia, Mamoona; (GB).
BRANCH, Clive, Leslie; (GB).
JAXA-CHAMIEC, Albert, Andrzej; (GB).
LAI, Justine, Yeun Quai; (GB).
NASH, David, John; (GB)
Agent: KONDO, Rie; GlaxoSmithKline, Corporate Intellectual Property (CN925.1) 980 Great West Road, Brentford, Middlesex TW8 9GS (GB)
Priority Data:
0701986.2 01.02.2007 GB
0701977.1 01.02.2007 GB
Title (EN) GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS
(FR) INHIBITEURS DU TRANSPORTEUR DE GLYT1 ET LEURS UTILISATIONS POUR LE TRAITEMENT DE TROUBLES NEUROLOGIQUES ET NEUROPSYCHIATRIQUES
Abstract: front page image
(EN)Compounds of Formula (I) or a salt thereof are provided: wherein R6, R7, R8, R21, X, Ar, and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further discloses pharmaceutical compositions and combinations comprising the compounds.
(FR)L'invention concerne des composés représentés par la formule (I) ou un de leurs sels, dans laquelle R6, R7, R8, R21, X, Ar et m correspondent à leur définition du descriptif. Elle concerne également des utilisations de ces composés en tant que médicaments, ainsi que pour la préparation de médicaments servant à traiter des troubles neurologiques et neuropsychiatriques, en particulier, des psychoses, la démence ou des troubles du déficit de l'attention. Elle concerne, de plus, des compositions pharmaceutiques et des combinaisons contenant ces composés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)