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1. (WO2008092831) PTERIDINONE DERIVATIVES AS PI3-KINASES INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/092831    International Application No.:    PCT/EP2008/050986
Publication Date: 07.08.2008 International Filing Date: 28.01.2008
IPC:
C07D 487/04 (2006.01), A61K 31/519 (2006.01), A61P 29/00 (2006.01), A61P 11/00 (2006.01)
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Binger Strasse 173, 55216 Ingelheim am Rhein (DE) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG [DE/DE]; Binger Str. 173, 55216 Ingelheim am Rhein (DE) (DE only).
GIOVANNINI, Riccardo [IT/DE]; (DE) (For US Only).
FRATTINI, Sara [IT/DE]; (DE) (For US Only).
BRANDL, Trixi [DE/DE]; (DE) (For US Only).
BREITFELDER, Steffen [DE/DE]; (DE) (For US Only).
CEREDA, Enzo [IT/DE]; (DE) (For US Only).
GRAUERT, Matthias [DE/DE]; (DE) (For US Only).
HOFFMANN, Matthias [DE/DE]; (DE) (For US Only).
JOERGENSEN, Anne T. [DK/DE]; (DE) (For US Only).
MAIER, Udo [DE/DE]; (DE) (For US Only).
PAUTSCH, Alexander [DE/DE]; (DE) (For US Only).
QUAI, Monica [IT/DE]; (DE) (For US Only).
SCHEUERER, Stefan [DE/DE]; (DE) (For US Only)
Inventors: GIOVANNINI, Riccardo; (DE).
FRATTINI, Sara; (DE).
BRANDL, Trixi; (DE).
BREITFELDER, Steffen; (DE).
CEREDA, Enzo; (DE).
GRAUERT, Matthias; (DE).
HOFFMANN, Matthias; (DE).
JOERGENSEN, Anne T.; (DE).
MAIER, Udo; (DE).
PAUTSCH, Alexander; (DE).
QUAI, Monica; (DE).
SCHEUERER, Stefan; (DE)
Agent: HAMMANN, Heinz; Boehringer Ingelheim GmbH, Binger Str. 173, 55216 Ingelheim am Rhein (DE)
Priority Data:
07101544.0 01.02.2007 EP
Title (EN) PTERIDINONE DERIVATIVES AS PI3-KINASES INHIBITORS
(FR) DÉRIVÉS DE PTÉRIDINONE SERVANT D'INHIBITEURS DES PI3-KINASES
Abstract: front page image
(EN)New compounds of Formula (1) are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.
(FR)L'invention concerne de nouveaux composés de formule (1) lesquels, en raison de leur activité pharmaceutique en tant que modulateurs des PI3-kinases, peuvent être utilisés dans le domaine thérapeutique pour le traitement de maladies inflammatoires ou allergiques. Les exemples de celles-ci comprennent des affections respiratoires inflammatoires et allergiques, des maladies inflammatoires du tractus gastro-intestinal et de l'appareil moteur, des maladies inflammatoires et allergiques de la peau, des maladies inflammatoires de l'œil, des maladies de la muqueuse nasale, des affections inflammatoires ou allergiques mettant en jeu des réactions auto-immunes ou des inflammations du rein.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)