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1. (WO2008092352) ANTITUMOR COMPOUNDS AND THEIR PREPARATION METHOD
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/092352    International Application No.:    PCT/CN2007/071183
Publication Date: 07.08.2008 International Filing Date: 06.12.2007
IPC:
C07D 209/86 (2006.01), C07D 401/12 (2006.01), C07D 209/12 (2006.01), C07D 307/80 (2006.01), C07D 333/56 (2006.01), A61K 31/4439 (2006.01), A61K 31/4433 (2006.01), A61K 31/403 (2006.01), A61P 35/00 (2006.01)
Applicants: INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES [CN/CN]; No.1 Tiantanxili, Chongwen District Beijing 100050 (CN) (For All Designated States Except US).
GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. [US/US]; University Plaza Atlanta, Georgia 30303 (US) (For All Designated States Except US).
HU, Laixing [CN/CN]; (CN) (For US Only).
BOYKIN, David, W. [US/US]; (US) (For US Only).
LI, Zhuorong [CN/CN]; (CN) (For US Only).
JIANG, Jiandong [CN/CN]; (CN) (For US Only)
Inventors: HU, Laixing; (CN).
BOYKIN, David, W.; (US).
LI, Zhuorong; (CN).
JIANG, Jiandong; (CN)
Agent: BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD.; 16th Fl., Block A, Corporate Square, No.35 Jinrong Street Beijing 100032 (CN)
Priority Data:
200710008244.4 26.01.2007 CN
Title (EN) ANTITUMOR COMPOUNDS AND THEIR PREPARATION METHOD
(FR) COMPOSÉS ANTITUMORAUX ET PROCÉDÉ PERMETTANT DE LES PRÉPARER
(ZH) 抗肿瘤化合物及其制备方法
Abstract: front page image
(EN)The invention provides new antitumor compounds, which are heterocyclic ketone (alcohol) or their derivatives having the structure of formula I. The compounds provided in the present invention can be used for preparing microtubulin protein inhibitors and have antitumor effect, and the invention also provides antitumor pharmaceutical compositions containing the said new compounds as active ingredient. The invention also provides the preparation method for the said compounds. The said compounds of formula I show the advantages of having a small molecular weight, being easy to synthesis and having less poison side effect.
(FR)Cette invention concerne des nouveaux composés antitumoraux, plus précisément des cétones hétérocycliques (alcool) ou leurs dérivés dont la structure est représentée par la formule I. Les composés décrits dans cette invention peuvent être utilisés pour préparer des inhibiteurs de protéines microtubulines et ils ont un effet antitumoral. Cette invention concerne également des compositions pharmaceutiques antitumorales contenant ces nouveaux composés en tant que principe actif. Cette invention concerne également un procédé permettant de préparer les composés. Les composés représentés par la formule I présentent l'avantage d'avoir un faible poids moléculaire, d'être simples à synthétiser et d'avoir moins d'effets secondaires toxiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)