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1. (WO2008090526) ORGANOMETALLIC COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2008/090526 International Application No.: PCT/IB2008/050273
Publication Date: 31.07.2008 International Filing Date: 25.01.2008
IPC:
C07F 17/02 (2006.01) ,A61K 31/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
17
Metallocenes
02
of metals of the iron group or the platinum group
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
28
Compounds containing heavy metals
Applicants:
THERRIEN, Bruno [CA/CH]; CH (UsOnly)
PADAVATTAN, Govindasvamy [IN/CH]; CH (UsOnly)
SÜSS-FINK, Georg [DE/CH]; CH (UsOnly)
ANG, Wee, Han [SG/US]; US (UsOnly)
DYSON, Paul, Joseph [GB/CH]; CH (UsOnly)
JUILLERAT, Lucienne [CH/CH]; CH (UsOnly)
SCHMITT, Frédéric [FR/CH]; CH (UsOnly)
UNIVERSITE DE NEUCHATEL [CH/CH]; Faubourg du Lac 5a, CP 3213 CH-2001 Neuchâtel, CH (AllExceptUS)
Inventors:
THERRIEN, Bruno; CH
PADAVATTAN, Govindasvamy; CH
SÜSS-FINK, Georg; CH
ANG, Wee, Han; US
DYSON, Paul, Joseph; CH
JUILLERAT, Lucienne; CH
SCHMITT, Frédéric; CH
Agent:
GANGUILLET, Cyril; ABREMA Agence Brevets et Marques, Ganguillet Avenue du Théâtre 16, CP 5027 CH-1002 Lausanne, CH
Priority Data:
07101258.726.01.2007EP
Title (EN) ORGANOMETALLIC COMPOUNDS
(FR) COMPOSÉS ORGANOMÉTALLIQUES
Abstract:
(EN) The present invention relates to novel organometallic compounds for use as a medicine, in particular in photodynamic therapy against various diseases, such as cancer or inflammatoryand/or immune disorders. The compounds comprise a central porphyrin or phtalocyanine backbone to which ligandlinkers coordinated to at least one transition metal are attached. Eta-5 or eta-6 arenes further bind to the transition metal. According to a preferred embodiment, the compound is a tetranuclear Ruthenium (+II) complex.
(FR) La présente invention porte sur de nouveaux composés organométalliques destinés à être utilisés comme médicament, en particulier dans une thérapie photodynamique contre diverses maladies, telles que le cancer ou des troubles inflammatoires et/ou immunitaires. Les composés comprennent un squelette central de porphyrine ou de phtalocyanine auquel sont attachés des éléments de liaison ligands coordonnés à au moins un métal de transition. Des êta-5 ou êta-6 arènes se lient en outre au métal de transition. Conformément à un mode de réalisation préféré, le composé est un complexe de Ruthénium (+II) tétranucléaire.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)