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1. WO2008082484 - 4,5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS

Publication Number WO/2008/082484
Publication Date 10.07.2008
International Application No. PCT/US2007/025754
International Filing Date 17.12.2007
IPC
C07D 209/60 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56Ring systems containing three or more rings
58- or -condensed
60Naphtho pyrroles; Hydrogenated naphtho pyrroles
C07D 401/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 491/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
C07D 401/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 491/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • SCHERING CORPORATION [US]/[US] (AllExceptUS)
  • CHEN, Kevin, X. [US]/[US] (UsOnly)
  • VENKATRAMAN, Srikanth [IN]/[US] (UsOnly)
  • NJOROGE, F., George [US]/[US] (UsOnly)
  • ROSENBLUM, Stuart, B. [US]/[US] (UsOnly)
  • LESBURG, Charles, A. [US]/[US] (UsOnly)
  • DUCA, Jose, S. [AR]/[US] (UsOnly)
  • SHIH, Neng-Yang [US]/[US] (UsOnly)
  • VELAZQUEZ, Francisco [MX]/[US] (UsOnly)
  • ANILKUMAR, Gopinadhan, N. [IN]/[US] (UsOnly)
  • ZENG, Qingbei [CN]/[US] (UsOnly)
  • KOZLOWSKI, Joseph, A. [US]/[US] (UsOnly)
Inventors
  • CHEN, Kevin, X.
  • VENKATRAMAN, Srikanth
  • NJOROGE, F., George
  • ROSENBLUM, Stuart, B.
  • LESBURG, Charles, A.
  • DUCA, Jose, S.
  • SHIH, Neng-Yang
  • VELAZQUEZ, Francisco
  • ANILKUMAR, Gopinadhan, N.
  • ZENG, Qingbei
  • KOZLOWSKI, Joseph, A.
Agents
  • BERGMAN, Jeffrey, P.
Priority Data
60/876,87722.12.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 4,5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS
(FR) DÉRIVÉS INDOLIQUES ANNULAIRES À NOYAU CYCLIQUE À 4 À 5 ÉLÉMENTS UTILISABLES POUR LE TRAITEMENT OU LA PRÉVENTION DES INFECTIONS PAR LE VHC ET AUTRE INFECTIONS VIRALES ASSOCIÉES
Abstract
(EN)
The present invention relates to 4,5-ring annulated indole derivatives, compositions comprising at least one 4,5-ring annulated indole derivatives, and methods of using the 4,5-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient. Wherein ring Z, of formula (I), is a cyclopentyl, cyclopentenyl, 5-membered heterocycloalkyl, 5-membered heterocycloalkenyl or 5-membered heteroaryl ring.
(FR)
La présente invention concerne des dérivés indoliques annulaires à noyau cyclique à 4 à 5 éléments, des compositions comprenant au moins un dérivé indolique annulaire à noyau cyclique à 4 à 5 éléments et des procédés d'utilisation des dérivés indoliques annulaires à noyau cyclique à 4 à 5 éléments pour le traitement ou la prévention d'une infection virale ou d'un trouble associé à un virus chez un patient, dérivés indoliques dans lesquels le noyau cyclique Z, de formule (I), est un noyau cyclopentyle, cyclopentényle, hétérocycloalkyle à 5 éléments, hétérocycloalcényle à 5 éléments ou hétéroaryle à 5 éléments.
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