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1. (WO2008070350) METHODS AND COMPOSITIONS RELATED TO WRAPPING OF DEHYDRONS

Pub. No.:    WO/2008/070350    International Application No.:    PCT/US2007/082893
Publication Date: Fri Jun 13 01:59:59 CEST 2008 International Filing Date: Tue Oct 30 00:59:59 CET 2007
IPC: C07D 401/14
A61K 31/506
A61P 35/02
Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
RICE UNIVERSITY
FERNANDEZ, Ariel
BORNMANN, William
LOPEZ-BERESTEIN, Gabriel
SANGUINO, Angela
PENG, Zhenghong
Inventors: FERNANDEZ, Ariel
BORNMANN, William
LOPEZ-BERESTEIN, Gabriel
SANGUINO, Angela
PENG, Zhenghong
Title: METHODS AND COMPOSITIONS RELATED TO WRAPPING OF DEHYDRONS
Abstract:
This application describes a novel technology in drug discovery and drug-based imaging/detection: the wrapping technology. This technology is based on identified singularities in the structure of soluble proteins. In contrast with drug-design approaches based on standard structural considerations, the packing of a protein, or more precisely, its dehydron pattern, may be used as a selectivity filter to design small-molecule inhibitors. The wrapping technology described herein is a novel form of rational drug design for avoiding side effects in drug therapy and sharpening the inhibitory impact of drugs on the oncokinome.