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1. (WO2008069824) COMPOSITIONS AND METHODS FOR TRANSPORT OF MOLECULES WITH ENHANCED RELEASE PROPERTIES ACROSS BIOLOGICAL BARRIERS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2008/069824 International Application No.: PCT/US2007/005375
Publication Date: 12.06.2008 International Filing Date: 27.02.2007
IPC:
A61K 47/48 (2006.01) ,A61K 38/00 (2006.01) ,C07K 2/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
2
Peptides of undefined number of amino acids; Derivatives thereof
Applicants:
WENDER, Paul, A. [US/US]; US (UsOnly)
GOUN, Elena, A. [RU/US]; US (UsOnly)
JONES, Lisa, R. [US/US]; US (UsOnly)
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; Office Of Technology Licensing 1705 El Camino Real Palo Alto, CA 94306, US (AllExceptUS)
Inventors:
WENDER, Paul, A.; US
GOUN, Elena, A.; US
JONES, Lisa, R.; US
Agent:
LINDER, Chris; Thomas, Kayden, Horstemeyer & Risley, LLP 600 Galleria Parkway Suite 1500 Atlanta,GA 30339, US
Priority Data:
60/777,34127.02.2006US
Title (EN) COMPOSITIONS AND METHODS FOR TRANSPORT OF MOLECULES WITH ENHANCED RELEASE PROPERTIES ACROSS BIOLOGICAL BARRIERS
(FR) COMPOSITIONS ET PROCÉDÉS POUR LE TRANSPORT DE MOLÉCULES AVEC DES PROPRIÉTÉS DE LIBÉRATION AMÉLIORÉES À TRAVERS DES BARRIÈRES BIOLOGIQUES
Abstract:
(EN) Conjugates of a cargo molecule with a transporter molecule are disclosed, where the cargo molecule and the transporter molecule are linked covalently by a releasable linker. The cargo of the conjugate can be a biologically active agent or a reporter molecule. The transporter modulates the transport of the cargo across a biological barrier (e.g., a cell membrane) compared to the transport of the unconjugated cargo. Releasable linkers suitable for rapid and facile conjugation to various types of cargo and transporters are also disclosed, along with methods for using the linkers in the synthesis of conjugates.
(FR) La présente invention concerne des conjugués d'une molécule cargo avec une molécule transporteuse, dans lesquels la molécule cargo et la molécule transporteuse sont liées de manière covalente par un lieur que l'on peut libérer. Le cargo du conjugué peut être un agent biologiquement actif ou une molécule rapporteuse. Le transporteur module le transport du cargo à travers une barrière (par exemple, une membrane cellulaire) par comparaison au transport du cargo non conjugué. La présente invention concerne également des lieurs que l'on peut libérer appropriés pour une conjugaison rapide et facile à divers types de cargos et de transporteurs, ainsi que des procédés d'utilisation de lieurs dans la synthèse de conjugués.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)