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1. (WO2008068637) OB-FOLD USED AS SCAFFOLD FOR ENGINEERING NEW SPECIFIC BINDERS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2008/068637 International Application No.: PCT/IB2007/004388
Publication Date: 12.06.2008 International Filing Date: 04.12.2007
IPC:
C07K 14/195 (2006.01) ,C12N 15/10 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
10
Processes for the isolation, preparation or purification of DNA or RNA
Applicants:
INSTITUT PASTEUR [FR/FR]; 28, Rue du Docteur Roux F-75015 Paris, FR (AllExceptUS)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR/FR]; 3, rue Michel Ange F-75016 Paris, FR (AllExceptUS)
PECORARI, Frédéric [FR/FR]; FR (UsOnly)
ALZARI, Pedro [IT/FR]; FR (UsOnly)
Inventors:
PECORARI, Frédéric; FR
ALZARI, Pedro; FR
Agent:
MARCADE, Véronique; Cabinet Ores 36, rue de St Pétersbourg F-75008 Paris, FR
Priority Data:
06291869.304.12.2006EP
Title (EN) OB-FOLD USED AS SCAFFOLD FOR ENGINEERING NEW SPECIFIC BINDERS
(FR) PLI OB UTILISÉ COMME ÉCHAFFAUDAGE POUR ÉLABORER DE NOUVELLES LIAISONS SPÉCIFIQUES
Abstract:
(EN) The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target selected amongst a large variety of ligands families. In particular, the present invention provides methods for obtaining a molecule specifically binding to a target of interest, through a combinatorial mutation/selection approach with an OB-fold protein as a starting molecule. In particular, the target of interest can be of a different chemical nature form that of the native target of the OB-fold protein used as the starting molecule.
(FR) L'invention concerne le domaine de l'ingénierie des protéines, et les moyens d'obtention de molécules stables susceptibles de se lier spécifiquement à une cible choisie dans une grande variété de familles de ligands. Plus précisément, l'invention concerne des procédés permettant d'obtenir une molécule se liant spécifiquement à une cible d'intérêt, par le biais d'une approche de mutation/sélection combinatoire avec une protéine à pli OB comme molécule de départ. Plus précisément, la cible d'intérêt peut être d'une formule de nature chimique différente, celle de la cible native de la protéine à pli OB utilisée comme molécule de départ.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
SG152829IL199057MXMX/a/2009/005949EP2099817JP2010511691US20100145008
EP2570424CN101652386CA2671553ES2536509DK2099817AU2007330409
IN3226/CHENP/2009