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1. WO2008059349 - METHOD OF FLUORINE-18 LABELLING OF TROPANE DERIVATIVES

Publication Number WO/2008/059349
Publication Date 22.05.2008
International Application No. PCT/IB2007/003476
International Filing Date 13.11.2007
IPC
C07D 451/02 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
451Heterocyclic compounds containing 8-azabicyclo octane, 9-azabicyclo nonane, or 3-oxa-9-azatricyclo nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
02containing not further condensed 8-azabicyclo octane or 3-oxa-9-azatricyclo nonane ring systems, e.g. tropane; Cyclic acetals thereof
CPC
C07D 451/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
451Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
02containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
Applicants
  • ORPHACHEM [FR]/[FR] (AllExceptUS)
  • DOLLE, Frédéric [FR]/[FR] (UsOnly)
  • EMOND, Patrick [FR]/[FR] (UsOnly)
  • LE GAILLIARD, Joël [FR]/[FR] (UsOnly)
  • HINNEN, Françoise [FR]/[FR] (UsOnly)
  • HELFENBEIN, Julie [FR]/[FR] (UsOnly)
Inventors
  • DOLLE, Frédéric
  • EMOND, Patrick
  • LE GAILLIARD, Joël
  • HINNEN, Françoise
  • HELFENBEIN, Julie
Agents
  • COLOMBET, Alain
Priority Data
06291762.014.11.2006EP
60/865,69414.11.2006US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF FLUORINE-18 LABELLING OF TROPANE DERIVATIVES
(FR) PROCÉDÉ DE MARQUAGE PAR LE FLUOR-18 DE DÉRIVÉS DU TROPANE
Abstract
(EN) The invention relates to a one-step [18F]radiolabelling process of tropanamine derivatives which are useful for imaging the neuronal dopamine transporter (DAT) with Positron Emission Tomography (PET).
(FR) L'invention porte sur un procédé de radiomarquage par [18F] en une étape des dérivés de tropanamine, qui sont utiles pour visualiser le transporteur de dopamine neuronal (DAT) à l'aide de la tomographie à émission de positons (PET).
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